**7. Early phagosome**

The newly formed phagosome rapidly gets the characteristics of the early endosome by fusing with sorting and recycling endosomes [34]. The interior becomes

acidic but not very destructive, the small GTPase Rab5 regulates the membrane fusion events between endosome and early endosome. This ATPase on the membrane is useful for the transition from the early to a late phagosome, Rab5 then works through the recruitment of EEA1 (early endosome antigen 1), that promotes the fusion of the new phagosome with early endosomes [35, 36]. Rab5 also recruits the classic PI-3 K human vacuolar protein-sorting 34, which then generates phosphatidylinostol3-phosphate [37]. The acidity of the early phagosome is activated by the recruitment of and action of V-ATPase accumulating on its membrane and also by accumulating on its membrane and also by transient fusions with more acidic vesicles. The V-ATPase Trans locates protons (H) lumen of the phagosome using cytosolic ATP as an energy source.
