**5.2 Heart diseases and cardiovascular diseases**

Macrophages are main cause in the onset of progressive plaque lesions in atherosclerosis. Residential M2 macrophages incorporate oxidised LDL in the cells and become form cells which clogging blood vessels. In addition, both M1 and M2 macrophages participate in the progression of atherosclerosis. M1 macrophages enhance atherosclerosis through inflammation induction. M2 macrophages eliminate cholesterol, but incorporated oxidised cholesterol induces apoptotic form cells from macrophages [14].

On the other hand, macrophages are recruited to the place where tissue regeneration is required after acute myocardial infraction, removing apoptotic cells and debris.
