**Abstract**

Phagocytosis is a critical component of the body's immune response, essential for preventing and controlling infections and defending against cancer cells. Macrophages and dendritic cells are the primary immune cells responsible for phagocytosis, recognizing and engulfing abnormal cells, including cancer cells. Although phagocytosis can prevent the spread of cancer cells by destroying them in a healthy immune system, cancer cells may evade this immune mechanism and form tumors. As an emerging therapeutic strategy, boosting phagocytosis is being utilized to target and eliminate cancer cells. This chapter provides an overview of the role of phagocytosis in cancer prevention and progression, highlighting its significance in the body's immune response to cancer. Furthermore, it explores various strategies and approaches to harness the power of phagocytosis in the fight against cancer.

**Keywords:** phagocytosis, ADCP, immune checkpoints, immunity, tumor microenvironment, rituximab, trastuzumab, dendritic cells
