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## Meet the editor

Tao Huang is a professor at the Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences. He completed his post-doctoral research at the Department of Genetics and Genomics Sciences, Icahn School of Medicine, Mount Sinai, New York City, USA. His research interests include bioinformatics, computational biology, systems genetics, and big data research. He has published more than 200 articles. He has been

an editor or guest editor for more than 30 journals and a reviewer for 230 journals. He was recognized as a Highly Cited Chinese Researcher in 2020, 2021, and 2022 and listed among the World's Top 2% of Scientists in 2020, 2021, and 2022.

### Contents


Preface

Epigenetics plays a crucial role in regulating gene expression, particularly in the field of transcriptomics. Dysfunctions in epigenetics have been identified as key factors in the development of cancer and numerous complex diseases. The ability to detect cancer at an early stage through the analysis of DNA methylation in blood samples has garnered significant interest in the field of liquid biopsy. This is because changes in DNA methylation patterns can be detected before changes in gene expression, making methylation analysis a more effective method for early cancer detection. By identifying signals of tumorigenesis, we can initiate treatment for cancer as early as

In addition to DNA methylation, there are numerous emerging areas of study in the field of epigenetics. These include research on the 3D genome, which is based on analyzing Hi-C data, as well as investigations into RNA modification through sequencing of N6-methyladenosine (m6A), N1-methyladenine (m1A), 5-methylcytidine (m5C),

In this book, we present the most recent advancements in epigenetics omics technologies and their utilization in understanding the mechanisms of cancer and complex diseases. Our intention is to provide readers with a comprehensive understanding of these technologies, inspiring them to adopt a multi-omics data integration approach in order to unravel the intricate mechanisms of epigenetic regulation in various biomedical contexts. We hope that this book will serve as an enlightening resource, broadening the horizons of our readers and motivating them to explore the potential of integrating multi-omics data for investigating epigenetic regulations in different

**Tao Huang**

Shanghai, China

Shanghai Institute of Nutrition and Health,

Chinese Academy of Sciences,

possible, thereby greatly improving the prognosis for patients.

and more.

biomedical scenarios.
