*Perspective Chapter: Functional Human Brain Connectome in Deep Brain Stimulation (DBS)… DOI: http://dx.doi.org/10.5772/intechopen.109855*

tool for brain sensing in PD patients with DBS implanted at STN, thereby facilitating DBS programming and medication titration. Increased beta activities were observed in the hypodopaminergic state when the patients suffer from bradykinesia and rigidity and could be suppressed by DBS and dopaminergic medications. On the other hand, increased gamma activities were seen in times of dyskinesia [65–69]. However, in patients with connectivity-based stimulation, will the electrophysiological data correlate with the connectivity profile? Accolla et al. described that beta oscillations were detected in the cerebral circuit projecting from the STN to the motor and premotor cortical areas in PD patients [70]. Besides, Hirschmann et al. reported that with the use of magnetoencephalography (MEG), local field potential (LFP) and electromyogram (EMG), elevated beta coherence was found between M1 and STN in PD patients, which could be suppressed with administration of levodopa [71]. These findings suggested a link between electrophysiology data and connectivity-based stimulation.

As such, connectomic DBS seems to be a reasonable and effective therapeutic option for advanced PD patients. Growing evidence has showed that depending on the symptoms, connectomic DBS can act on different circuits in the brain. In this way, the neuromodulation surgery can affect both motor and non-motor functions (**Table 2**) [23, 45, 61, 72–79].



**Table 2.**

*Clinical effects of connectomic DBS in PD.*
