**7. TMS and connectome**

Connectome, the concept first introduced by Professor Sporns, is the connection matrix of human brain, which refers to the complete set of structural connections between neurons of the brain [65]. Diseases or cerebral insults cause disruption of the connectome. Diaschesis and vicaration of function, together with homeostatic mechanism of neuroplasticity, help to restore neurological functions which can be demonstrated by TMS in cortical remapping, i.e., detection of shift of stimulation hotspots compared with premorbid state. TMS, at the same time, is also considered as an non-invasive and safe tool to modulate the reconstruction of connectome after insult during the rehabilitation phase [18].
