*6.1.4 Schizophrenia*

Stanford et al. suggested that negative symptoms appeared to be associated with hypoactivity of the dorsolateral prefrontal cortex of the brain while positive symptoms, particularly auditory hallucination, appeared to be associated with hyperactivity in the left temporo-parietal cortex [30]. Therefore, high-frequency rTMS at dorsolateral prefrontal cortex was suggested for negative symptoms and low-frequency rTMS at left temporo-parietal cortex for positive symptoms. Meta-analyses show the clinical improvement for the mentioned protocol with p value 0.002 [31, 32]. Goh et al. found that iTBS given to left dorsolateral prefrontal cortex was also effective in treating negative symptoms of schizophrenia with a p value of 0.004 [33].
