**2. Distribution of probiotic articles by type disease**

**Figure 2** shows the distribution of meta-analysis probiotic articles published from 2000 to 2020 by anatomical of physiological target. The greatest number of studies were associated with digestive system diseases (139 out of 283 or 49.11% of the total) and the least of them were related to disorders of the nervous system, eye, and adnexa. **Figure 2** illustrates the proportion of probiotics in the treatment of different diseases as well.
