**7. Conclusion**

Dysbiotic patients having NAFLD displayed significant elevation of inflammatory acute phase reactant proteins such as PCT and CRP. Significant increase of the cytolytic enzymes like alanine aminotransferase (ALT) and other biological variables like LDL-cholesterol, triglycerides, and HbA1c was also noted. Patients with NAFLD from the dysbiotic group exhibited significant differences related to higher FLI and severity of fatty liver either simple steatosis or NASH. Less often treatment with biguanides and statins was recorded in patients with fatty liver and gut dysbiosis. The gut microbiome of the patients with NAFLD was characterized by various alterations. The decrease of some bioindicators, such as H index of biodiversity, *A. muciniphila* sp*.*, and F/B ratio, was frequently observed. However, other species, namely, LPS (+), were often found abundant. The enterotypes of patients with NAFLD and dysbiosis were characterized mostly by *Bacteroides* sp. and *Prevotella* spp. and rarely by *Ruminococcus spp.* Strong positive correlations were observed between PCT and some blood biological variables, such as ALT and CRP, as well as between PCT and some stool's microbiota bioindicators, such as F/B ratio and stool's H index of alpha biodiversity. Gut dysbiosis of patients with NAFLD was significantly positively correlated with the severity of NASH scores. All these correlations between PCT and various bioindicators of the gut microbiome and also between dysbiosis and NASH severity suggest that these three entities, namely, PCT, dysbiosis, and NAFLD, are closely related.
