**1. Introduction**

Microbiomics is the science that distinguishes the structure, role, and passage of molecules involved in the microbial group [1]. In the "omics" era, it became more and more clear that gut microbiota is probably impacting the entire metabolism of the host. The study of the microbial community in their own habitat allows us to understand the complex interactions between microorganisms and the molecules responsible for their maintenance and correct functioning [1]. The microbiome, considered the metagenome of the microbiota, consists of the genetic material of bacteria, fungi, protozoa, and viruses, which can be found on the skin or hair surfaces, on mucosal surfaces (oral, intestinal, airways [2], vaginal [3]); uterus [4], eyes [5], and lungs [6]) [7].

Humans and microorganisms have coexisted for millennia under symbiotic relationships [7]. Any alteration in the human microbiome can lead to an imbalance stated, called dysbiosis, which influences the evolution of different conditions [8]. Dysbiosis can occur due to a series of factors like environment conditions (cold temperatures, poor economic status), treatment with antibiotics, probiotics intake, acute or chronic infections, or even the immune status of the host [9].

The gut microbiota is responsible for generating biologically active metabolites, with important roles in homeostasis, but also in pathophysiological processes [7].

Gut microbiota is involved in maintaining the immunological barrier, providing nutrients, and generating energy [10].
