**Abstract**

Emergent economically important diseases affecting the poultry industry in the face of commercial vaccination programs in place might require custom-made vaccines to be controlled in the field. These custom-made vaccines ("autogenous"), albeit requiring less regulatory burden than fully licensed commercial vaccines, are restricted in their scope and field isolates and can only be used in particular areas/ operations. This chapter summarizes field and research experience of the author with some viral and bacterial autogenous vaccine programs (e.g., Avian Reovirus, Fowl Adenovirus, Infectious Bursal Disease Virus, *Salmonella enterica* spp., *Escherichia coli*, *Clostridium spp*.), as well as commentaries on regulations, and adjuvant technologies used in the poultry industry.

**Keywords:** autogenous vaccines, vaccine candidate selection, challenge evolution, poultry, autogenous vaccine program considerations
