**Abstract**

Plants respond to climate change *via* sensing the extreme environmental conditions at cell level, which initiated significant changes in their physiology, metabolism, and gene expression. At the cell membrane, plants activate certain genes (like GRP, PRP, AGP) to provide strengthening to cell wall. Drought and salinity stress tolerance attained by osmotic adjustments, activation of transcriptional factors (like AREB, ABF, DREB2), and regulation of Na+ homeostasis *via* transporters (like NSCC, NHX1, SOS1, HKT1, LTC1). For adaptations to chilling and frost stress, plants use hydrophobic barriers (waxes/cuticles), antinucleator (cryoprotective glycoprotein), and antifreeze proteins. Higher expression of HSPs (heatshock proteins such as HSP70, HSP100, HSP90, HSP60) is important for thermal tolerance. Tolerance to heavy metal (HM) stress can be achieved *via* vacuolar sequestration and production of phytochelatin, organic acids and metallothionein. ROS generated due to abiotic stresses can be alleviated through enzymatic (APX, CAT, POD, SOD, GR, GST) and nonenzymatic (ascorbate, glutathione, carotenoids, flavonoids) antioxidants. Genetic manipulation of these genes in transgenic plants resulted in better tolerance to various abiotic stresses. Genetic engineering of plants through various genome editing tools, such as CRISPR/Cas9, improve the abiotic stress tolerance as well as enhance the crops' quality, texture, and shelf life.

**Keywords:** climate change, molecular mechanisms, abiotic stress, adaptations, genome editing
