*3.1.1 Memory of plant immunization*

Advances in the knowledge of epigenetic regulation in the plant multiple generation stress memory have provided new procedures and approaches for breeding crops and sustainable germplasm banks for future climate challenges [112, 113]. Plant stress memory is described under two categories: mitotic stress memory, or somatic memory, and meiotic stress memory, or transgenerational memory [114–116]. Plant stress memory associated with the inheritance of SAR is likely to be epigenetic [117, 118]. In plants, defense priming and SAR are associated with epigenetic modifications of histones, DNA methylation, increased signaling enzymes, and an accumulation of pattern recognition receptors (PRRs) at cell membranes [119, 120]. In summary, strategies exploiting epigenetic variations appear promising for crop resistance breeding [121–124].
