**2. Richness of south African diverse population in herbs using for cancer**

South Africa have nine provinces (**Figure 1**) with a population of almost 60million, 11 spoken official languages (**Figure 2**) across with English and Afrikaans spoken by many, high unemployment rate that was escalated by the global pandemic, that encouraged traditional people to even rely on and practice the use of medicinal plants [1, 2]. Indigenous knowledge played a major role for many decades for alleviation of the diseases [3]; however, less was known to the effect that some of this herb's extracts does to the human body as most patients where happy to see the reduction to clearing of infections and the clinical symptoms possible linked to the disease at that time. This chapter will bring the documented herbs and report on the different studies done in assessing the safeness of these extracts and a conclusion will be drawn as an awareness for which plants should our people practicing tradition medicine should be aware of. Scopus, Google Scholar, Web of Science, ScienceDirect, PubMed, and books, as well as local reports and thesis submissions, were used to conduct a broad literature search.
