**2. Methodology**

The MeSH (Medical Subject Headings) databases are the NLM controlled vocabulary thesaurus that were used for indexing articles such as occupational stress in workplaces, related diseases, factors affecting stress, consequences, occupational stress physiology and neurobiology, hormones involved in stress neurobiology and its mechanism of action, stress responsive parathyroid hormone (PTH) in occupational settings, stress responsive protein in occupational settings, oxidative stress markers in industrial based mining workers. Initial searches limited to materials available with complete abstracts and those available in the English language were included. Published articles were searched from numerous electronic databases including PubMed, Google, Cochrane library, free PMC article, koreamed, hinari publication, scopus indexed journal, virtual health library, audicus, NCBI databases, Indexing of Indian Medical Journals (INDMED), and PakMediNet—Medical Information Gateway of Pakistan etc. Systematic reviews, book chapters, review and research papers, and case studies pertaining to workplace stress in industrial settings were also included. Articles about stress in healthcare facilities, IT workplaces, academic institutions, and government institutions were omitted. Articles that only described the procedures or offered opinions or news were also disqualified. The review chapter were includes literature from 1986 to 2021 period (last 20 years) to study oxidative stress in mining based industrial subjects. A total of (n = 104) papers were chosen that discussed the effects of occupational stress on industrial employees' biochemistry and pathophysiology in stress conditions. According to the electronic database, very few published articles regarding stress protein expression in occupational stress conditions in mining based industrial workers from India were reported, This review chapter, discussed about occupational stress and its associated factors in workers which is continuously exposed to chemicals, dust, environmental pollutants, and hazardous toxicants had impact on their biochemical, pathophysiological, molecular, neurological, immunological, endocrine, and respiratory mechanisms alteration in them. These alteration may provide future insights regarding importance of occupational stress in them at workplace environment.
