**6. Synthesis and conclusion**

The evolution of best performing healthcare systems relies on all the essential elements presented in this textbook, including patient safety education, teambased approaches, accurate safety data collection and processing, the development of patient safety champions, as well as non-judgmental, self-learning, and selfcorrecting systems. Despite significant improvements during the past two decades, the achievement of sustained zero-defect patient safety performance continues to be as elusive as ever. With increasingly complex healthcare systems, where information and technology tend to evolve faster than an average clinician-stakeholder's ability to
