**Funding**

These researches were funded by the Taiwan National Science Council (Grant Number NSC99-2511-S-255-001-MY2, NSC102-2511-S-255-004-MY2) and Chang Gung Memorial Hospital.

The data that support the findings of these studies are available on request from the Principal Investigator, M.-Y.Y.

The data are not publicly available due to their containing information that could compromise the privacy of research participants.
