**2.1 Musculoskeletal infection**

18F-FDG has proved to be very useful for diagnosing osteomyelitis (**Figure 2**). In one systematic review, 18F-FDG PET had a pooled sensitivity of 0.92 (95% CI: 0.87–0.96) and a pooled specificity of 0.92 (95% CI: 0.87–0.96) for the diagnosis of osteomyelitis, for a positive likelihood ratio of 9.77 (95% CI: 5.99–15.95) and a negative likelihood ratio of 0.12 (95% CI: 0.07–0.20). The area under the summary receiver operating characteristics curve was 0.97 [6]. In another systematic review, 18F-FDG PET had a pooled sensitivity of 0.96 (95% CI: 0.88–0.99) and a pooled specificity of 0.91 (95% CI: 0.81–0.95) for diagnosing chronic osteomyelitis [7].
