**Abstract**

The modern development and improvement of mathematical models that describe the radiobiology of processes in the body occurring under the influence of radiation every year lead to more complicated calculations related to the estimation of its impact both on the effectiveness of radiotherapy and on the possibility of making changes to the radiation treatment regimen. This significantly increases the time spent by medical physics and radiation oncologists and also requires special training of qualified specialists capable of performing such calculations. The aim of the study is to optimize calculations related to the estimation of radiation doses when the radiation treatment schedule changes, by modeling such changes with specially designed software on the basis of the theory of a linear-quadratic radiobiological model. The Web application is accessed *via* the Internet link https://hypo-calc.github.io/. As an example of using the Web application, the possible cases in clinical practice are considered.

**Keywords:** radiobiology, radiobiological models, linear-quadratic model, incomplete reparation, proliferation
