**6. Hypogonadism, infertility and pregnancy complications**

WT is predominantly diagnosed in prepubertal children, with the incidence peaking at 12 months in males and 12–36 months in females, and is among the few malignancies that occurs more frequently in females than males [30]. With current therapeutic regimens that include the of large chest and flank/ WART fields, it is important to consider the impact of these treatments on gonadal function and

reproduction in WT survivors. The potential RT exposure of the gonads can range from internal scattered doses only (e.g., flank RT) to full RT dose (e.g., whole abdomen [WART] in females).
