**2.2 Association IN patients with head and neck CANCER**

There is still no systematic review that summarizes the data on SNPs in the prediction of ARD in patients with head and neck cancer. Therefore, the evidence discussed here comes from a quick literature search.

The rs3755557 SNP in *GSK3β* in the allelic model was reported [62] to have a statistically significant association with the development of severe ARD, considered to be a manifestation of moist desquamation. This gene participates in a number of tissue repair and inflammation pathways [63]. Therefore, it is hypothesized that polymorphisms in this gene may be associated with loss of function in the pathways and decreased tissue repair [56].

Borchiellini et al. [64] demonstrated an association between the GG genotype of SNP rs2279744 in *MDM2* and a 1.23-fold increase in the risk of severe ARD. This gene is responsible for *TP53* degradation [65].


#### **Table 1.**

*Single-nucleotide polymorphisms (SNPs) associated with acute radiation dermatitis (ARD) in the study by Aguiar et al. [48].*

*Radiogenomics: A Personalized Strategy for Predicting Radiation-Induced Dermatitis DOI: http://dx.doi.org/10.5772/intechopen.108745*

*XRCC1* plays an important role in DNA repair following base excision damage [66]. Nanda et al. [67] and Raturi et al. [68] found that polymorphic variants in *XRCC1* for the SNP encoded by rs1799782 increased the risk of developing severe ARD. Additionally, Li et al. [69] found that polymorphic variants in this gene for the SNP encoded by rs25487 also increased the risk of developing severe ARD.
