**4. Conclusions**

Calculations related for the evaluation of the effectiveness of radiotherapy and the possibility of making changes to the radiation treatment regimen require special training of qualified specialists who are able to carry out such calculations. We have developed a computer program that allows us to optimize the work associated with the estimation of radiation doses. The application was developed with no funding. In this version, not all functions related to the evaluation of radiation doses are implemented.

The tasks in this chapter are taken from the lectures from the training courses by the IAEA in cooperation with the Government of the Russian Federation through the State Research Centre—Burnasyan Federal Medical Biophysical Centre of Federal Medical Biological Agency "Regional Training Course on Radiobiology for Radiation Oncologists and Medical Physicists" 2018 and the AMPR "Virtual Regional Training Course on Transition from 3D Conformal Radiation Therapy to Intensity Modulated Radiation Therapy" 2021. The calculation of isoeffective doses, calculation of the number of fractions, calculation of amendments for the modified treatment regimen, calculation of EQD2 taking into account the interruptions in RT course, calculation of EQD2 taking into account the reduction of days of treatment, accounting for incomplete reparation with multi-fraction irradiation per day, and the possibility of correcting errors in the release of the dose are considered in detail.

Description of the multicomponent and multidirectional response of the body to the action of ionizing radiation in the form of simple mathematical expressions, aimed at the treatment of malignant neoplasms within an acceptable range of complications, is a difficult task. Each modification of radiobiological models allows going deeper into biology, expanding the boundaries of applicability, and overcoming an increasing number of shortcomings. The treatment of tumor diseases is currently different for adults and children, but often there is no difference in the treatment of men and women. In addition, great importance is given to genetics, but the issues of epigenetics remain aside.
