**2.1 BRCA1-Associated TNBC**

Basal-like tumors show similar molecular genetic profiles to tumors arising in BRCA1 carriers. Both sporadic basal-like tumors and tumors with BRCA 1 mutations express basal keratins, and both groups cluster together in gene expression profiling [9]. Germline mutations for BRCA genes occur in 10–20% of TNBC patients, and somatic mutations are seen in 3–5% [10]. Apart from somatic mutation in BRCA1 gene: [5, 6]

	- a. Extreme genomic instability and sensitivity to DNA-crosslinking agents
