**3. Conclusions**

Histoplasmosis is an underdiagnosed infection that affects both immunocompromised and healthy individuals, and early diagnosis requires a high clinical suspicion by clinicians. Management decisions in these patients must balance the severity and localization of the disease, the degree of immunosuppression, the necessity of immunosuppression, the interaction of antifungal drugs, the side effect, the tolerance, and the adherence to treatment. Systematically statements and guidelines assist practitioners and patients in making decisions about appropriate health care for specific clinical circumstances.

*Histoplasmosis: An Overview Treatment of Histoplasmosis DOI: http://dx.doi.org/10.5772/intechopen.110365*
