**3. Pulmonary histoplasmosis-framework**

Most people exposed to *H. Capsulatum* infection will have a mild, even asymptomatic form of the disease, with up to 90% of cases going undiagnosed. However, those under 2 years old and over 50, considered extreme ages, may develop more severe symptoms, with a febrile syndrome, dyspnea, cough, chest pain, and abdominal pain, approximately 2 weeks after exposure. Frequently, the disease is self-limiting, but in case of inhalation of a large inoculum, diffuse histoplasmosis can occur, with severe manifestations, especially dyspnea [3].

The spectrum of imaging changes found in histoplasmosis shows substantial variability, depending on the patient's immunological status, the amount of inoculum at the time of infection, and the organs or systems involved. The radiological lesion pattern can mimic pathologies much more frequently encountered in medical practice, such as community-acquired pneumonia, tuberculosis, and bronchopulmonary neoplasm, but also other pulmonary fungal diseases, which underlines the difficulty of a prompt and certain diagnosis [4].

At the two opposite poles in terms of imaging diagnosis, we identify cases of subclinical histoplasmosis, in which the chest x-ray is present within normal limits, going up to the acute disseminated form with nodular miliary pattern and diffuse pulmonary distribution, such as systemic damage.
