**8. Conclusions**

In North and Latin America, histoplasmosis is the most common endemic fungal infection, but a number of cases have been reported from many areas of the world. In patients who have lived outside endemic areas, a differential diagnosis with HPM should be considered if there is a history of travel or residence in endemic areas.

As a result of climate change, the epidemiology of endemic invasive fungal infections is changing. The exact incidence of HPM throughout the world is still unknown. There is an urgent need to establish a global traceability system to learn more about the diseases.

Disseminated HPM could be diagnosed at an early stage using time-saving methods without cultures, which would reduce hospitalization costs and increase patient survival.

There is an urgent need for newer, faster, and more sensitive diagnostic tools to be available in clinical laboratories around the world to enable faster diagnosis, which plays an important role in improving patient outcomes in the clinic.
