[7] Martínez-Gamboa A,

Niembro-Ortega MD, Torres-González P, Santiago-Cruz J, Velázquez-Zavala NG, Rangel-Cordero A, et al. Diagnostic accuracy of antigen detection in urine and molecular assays testing in different

clinical samples for the diagnosis of progressive disseminated histoplasmosis in patients living with HIV/AIDS: A prospective multicenter study in Mexico. PLoS Neglected Tropical Diseases. 2021;**15**(3):e0009215. DOI: 10.1371/ journal.pntd.0009215

[8] Cáceres DH, Gómez BL, Tobón AM, Chiller TM, Lindsley MD. Evaluation of a *Histoplasma* antigen lateral flow assay for the rapid diagnosis of progressive disseminated histoplasmosis in Colombian patients with AIDS. Mycoses. 2020;**63**:139-144. DOI: 10.1111/ myc.13023

[9] Cáceres DH, Gómez BL, Tobón ÁM, Minderman M, Bridges N, Chiller T, et al. Validation and concordance analysis of a new lateral flow assay for detection of *Histoplasma* antigen in urine. Journal of Fungi. 2021;**7**(10):799. DOI: 10.3390/ jof7100799

[10] Cáceres DH, Gómez BL, Tobón ÁM, Chiller TM, Lindsley MD. Evaluation of OIDx *Histoplasma* urinary antigen EIA. Mycopathologia. 2022;**187**(1):129-131. DOI: 10.1007/s11046-021-00602-9

[11] Second WHO Model List of Essential in Vitro Diagnostics. Geneva: World Health Organization; 2019 (WHO/ MVP/EMP/2019.05). Available from: https://www.who.int/medical\_devices/ publications/TRS\_1022\_SAGE\_IVD\_ Second\_WML\_of\_Essential\_In\_Vitro\_ Diagnostics/en/. [Accessed: 2023-02-22]

[12] Caceres DH, Adenis A, de Souza JV, Gomez BL, Cruz KS, Pasqualotto AC, et al. The Manaus declaration: Current situation of histoplasmosis in the Americas, report of the II regional meeting of the international histoplasmosis advocacy group. Current Fungal Infection Reports. 2019;**13**:244- 249. DOI: 10.1007/s12281-019-00365-3

[13] Wheat LJ. Improvements in diagnosis of histoplasmosis. Expert Opinion on Biological Therapy. 2006;**6**(11):1207-1221. DOI: 10.1517/14712598.6.11.1207

[14] Wheat LJ, Connolly-Stringfield P, Williams B, Connolly K, Blair R, Bartlett M, et al. Diagnosis of histoplasmosis in patients with the acquired immunodeficiency syndrome by detection of *Histoplasma capsulatum* polysaccharide antigen in bronchoalveolar lavage fluid. American Review of Respiratory Disease. 1992;**145**(6):1421-1424. DOI: 10.1164/ ajrccm/145.6.1421

[15] Hage CA, Davis TE, Fuller D, Egan L, Witt JR III, Wheat LJ, et al. Diagnosis of histoplasmosis by antigen detection in BAL fluid. Chest. 2010;**137**(3):623-628. DOI: 10.1378/chest.09-1702

[16] Swartzentruber S, Rhodes L, Kurkjian K, Zahn M, Brandt ME, Connolly P, et al. Diagnosis of acute pulmonary histoplasmosis. Clinical Infectious Diseases. 2009;**49**(12):1878- 1882. DOI: 10.1086/648421

[17] Wheat LJ. Laboratory diagnosis of histoplasmosis: Update 2000. Seminars in Respiratory Infections. 2001;**16**(2):131-140. DOI: 10.1053/ srin.2001.24243

[18] Wheat LJ, Musial CE, Jenny-Avital E. Diagnosis and management of central nervous system histoplasmosis. Clinical Infectious Diseases. 2005;**40**(6):844-852. DOI: 10.1086/427880

[19] Hage CA, Azar MM, Bahr N, Loyd J, Wheat LJ. Histoplasmosis: Up-todate evidence-based approach to diagnosis and management. Seminars

in Respiratory and Critical Care Medicine. 2015;**36**(5):729-745. DOI: 10.1055/s-0035-1562899

[20] Wheat J, Wheat H, Connolly P, Kleiman M, Supparatpinyo K, Nelson K, et al. Cross-reactivity in *Histoplasma capsulatum* variety *capsulatum* antigen assays of urine samples from patients with endemic mycoses. Clinical Infectious Diseases. 1997;**24**(6):1169- 1171. DOI: 10.1086/513647

[21] Kuberski T, Myers R, Wheat LJ, Durkin M, Connolly P, Kubak BM, et al. Diagnosis of coccidioidomycosis by antigen detection using cross-reaction with a *Histoplasma* antigen. Clinical Infectious Diseases. 2007;**44**(5):e50-e54. DOI: 10.1086/511684

[22] Vergidis P, Walker RC, Kaul DR, Kauffman CA, Freifeld AG, Slagle DC, et al. Falsepositive aspergillus galactomannan assay in solid organ transplant recipients with histoplasmosis. Transplant Infectious Disease. 2012;**14**:213-217. DOI: 10.1111/ j.1399-3062.2011. 00675.x

[23] Wheat LJ, Connolly P, Durkin M, Book BK, Tector AJ, Fridell J, et al. Falsepositive *Histoplasma* antigenemia caused by antithymocyte globulin antibodies. Transplant Infectious Disease. 2004;**6**(1):23-27. DOI: 10.1111/ j.1399-3062.2004.00045.x

[24] Guimarães AJ, Nosanchuk JD, Zancopé-Oliveira RM. Diagnosis of histoplasmosis. Brazilian Journal of Microbiology. 2006;**37**:1-3. DOI: 10.1590/ S1517-83822006000100001

[25] Kauffman CA. Histoplasmosis: A clinical and laboratory update. Clinical Microbiology Reviews. 2007;**20**(1):115-132. DOI: 10.1128/ CMR.00027-06

*Histoplasmosis: Laboratory Diagnosis DOI: http://dx.doi.org/10.5772/intechopen.112411*

[26] Picardi JL, Kauffman CA, Schwarz J, Phair JP, Andersen J, Warth P. Detection of precipitating antibodies to *Histoplasma capsulatum* by counterimmunoelectrophoresis. American Review of Respiratory Disease. 1976;**114**(1):171-176. DOI: 10.1164/ arrd.1976.114.1.171

[27] Bauman DS, Smith CD. Comparison of immunodiffusion and complement fixation tests in the diagnosis of histoplasmosis. Journal of Clinical Microbiology. 1975;**2**(2):77-80. DOI: 10.1128/jcm.2.2.77-80.1975

[28] Bloch KC, Myint T,

Raymond-Guillen L, Hage CA, Davis TE, Wright PW, et al. Improvement in diagnosis of *Histoplasma* meningitis by combined testing for *Histoplasma* antigen and immunoglobulin G and immunoglobulin M anti-*Histoplasma* antibody in cerebrospinal fluid. Clinical Infectious Diseases. 2018;**66**(1):89-94. DOI: 10.1093/cid/cix706

[29] Datta K, LaRue R, Permpalung N, Das S, Zhang S, Mehta Steinke S, et al. Development of an interferongamma release assay (IGRA) to aid diagnosis of histoplasmosis. Journal of clinical microbiology. 2022;**60**(10):e01128-e01122. DOI: 10.1128/jcm.01128-22

[30] Hage CA, Knox KS, Davis TE, Wheat LJ. Antigen detection in bronchoalveolar lavage fluid for diagnosis of fungal pneumonia. Current Opinion in Pulmonary Medicine. 2011;**17**(3):167-171. DOI: 10.1097/ MCP.0b013e3283447b60

[31] Valero C, Buitrago MJ, Gago S, Quiles-Melero I, García-Rodríguez J. A matrix-assisted laser desorption/ ionization time of flight mass spectrometry reference database for the identification of *Histoplasma capsulatum*. Medical Mycology. 2018;**56**(3):307-314. DOI: 10.1093/mmy/myx047

[32] Chen J, Li Y, Li Z, Chen G, Liu X, Ding L. Metagenomic next-generation sequencing identified *Histoplasma capsulatum* in the lung and epiglottis of a Chinese patient: A case report. International Journal of Infectious Diseases. 2020;**101**:33-37. DOI: 10.1016/j. ijid.2020.09.038

[33] Valero C, Martín-Gómez MT, Buitrago MJ. Molecular diagnosis of endemic mycoses. Journal of Fungi. 2022;**9**(1):59. DOI: 10.3390/jof9010059

[34] Vetter E, Torgerson C, Feuker A, Hughes J, Harmsen S, Schleck C, et al. Comparison of the BACTEC MYCO/F lytic bottle to the isolator tube, BACTEC plus aerobic F/bottle, and BACTEC anaerobic lytic/10 bottle and comparison of the BACTEC plus aerobic F/bottle to the isolator tube for recovery of bacteria, mycobacteria, and fungi from blood. Journal of Clinical Microbiology. 2001;**39**(12):4380-4386. DOI: 10.1128/ JCM.39.12.4380-4386.2001

[35] Smith CD, Goodman NL. Improved culture method for the isolation of *Histoplasma capsulatum* and Blastomyces dermatitidis from contaminated specimens. American Journal of Clinical Pathology. 1975;**63**(2):276-280. DOI: 10.1093/ajcp/63.2.276

[36] Donnelly JP, Chen SC, Kauffman CA, Steinbach WJ, Baddley JW, Verweij PE, et al. Revision and update of the consensus definitions of invasive fungal disease from the European Organization for Research and Treatment of cancer and the mycoses study group education and research consortium. Clinical Infectious Diseases. 2020;**71**(6):1367-1376. DOI: 10.1093/cid/ ciz1008

[37] Gupta N, Arora SK, Rajwanshi A, Nijhawan R, Srinivasan R. Histoplasmosis: Cytodiagnosis and review of literature with special emphasis on differential diagnosis on cytomorphology. Cytopathology. 2010;**21**(4):240-244. DOI: 10.1111/j.1365-2303.2009.00693.x
