**9. Conclusions**

Histoplasmosis overlapping HIV-pandemic redefined the epidemiology and the clinical features of this disease, generating a particular form in AIDS: progressive disseminated histoplasmosis. Challenges in diagnosis (especially in non-endemic areas where a significant knowledge gap still exists), treatment (due to drug-drug interactions between fungicidal drugs and cART, and availability of medications) and association with other opportunistic infections (especially tuberculosis) have determined specialists to release guidelines but also research priorities. Hopefully, access to antiretroviral medication for all HIV patients will change the face of this pathology till new strategies will be available in order to control this potentially life-threatening illness.

*HIV-Associated Histoplasmosis DOI: http://dx.doi.org/10.5772/intechopen.111389*
