**5. Non nucleoside reverse transcriptase inhibitors (NNRTIs)**

Non nucleoside reverse transcriptase inhibitors (NNRTI's) causing an allosteric inhibition of reverse transcriptase enzyme by binding directly to enzyme at different site of nucleoside binding component. Nevirapine, delavirdine and efavirenz are the

*Substituted Azoles as Non-Nucleoside Reverse Transcriptase Inhibitors Activity DOI: http://dx.doi.org/10.5772/intechopen.110758*

three members of this group which are used clinically. These agents are given in combination with other antiviral compounds for the treatment of AIDS. All class of NNRTI's are rapidly absorbed from gastrointestinal tract and with highly bound plasma proteins. These NNRTI's are extensively metabolized by cytochrome P450 enzyme along with variable amount of administered drug which are being recovered from urine as a metabolite. Skin rashes is the most common adverse effect associated with NNRTI class of drugs [25].
