*Recent Methods for Synthesis of Coumarin Derivatives and Their New Applications DOI: http://dx.doi.org/10.5772/intechopen.108563*

coumarin heterocyclic ring system is widely used mostly in pharmaceutical industry to build a various functional groups present in the drug molecules. Significant research has been shown to isolate and purify naturally present biological active coumarins from a range of plants, animals, and microbes, and to artificially design and synthesize functionalized coumarin molecules from academic and industry as well with unique heterocyclic structures and characteristics [31–36]. Given the importance of coumarin parent compounds and their derivatives in medicinal chemistry, we have gathered diverse methods for the preparation of coumarin and its scaffolds from alkyne type aryl propiolate as suitable starting materials *via* transition metal and, non-metal mediated catalysis and photo-chemical and radical based transformations. In this chapter, we mostly tried to cover the traditional name reactions mediated coumarin synthesis and described new synthetic methods to access coumarin heterocycles and also showed recent exciting applications which are reported in recent years. As a result, we think that this book chapter will be useful for not just the students but for researchers and scientists as well, who are trying to figure out new ways to build complicated coumarins, therapeutic compounds based on coumarins, and polycyclic coumarin derivatives.
