**3.1 Capravirine**

Capravirine (formerly known as S-1153 or AG1549) is a 1,2,4,5-substituted imidazole derivative (**Figure 2**) that inhibits HIV-1 replication in a standard CD4<sup>+</sup> .

Capravirine exhibited significant expansion as antiviral spectrum as anti HIV agent and covered many typical resistant mutant strain of NNRTI including single K103N mutation and double K103N-L100I and K103N-P225H mutations [18–20]. Y181C was also other common mutation which arises under nevirapine pressure and also inhibited by capravirine [21].

Barreca et al. were carried out their research in the fields of Non nucleoside reverse transcriptase inhibitors (NNRTIs).
