**Abstract**

Thiazolidinone scaffold has become a highly powerful scaffold in the current era when it comes to its clinical importance. Its wide variety of biological functions have piqued the researchers' intense curiosity. The 1,3-thiazolidin-4-ones have numerous pharmacological properties, including anti-cancer, anti-diabetic, anti-microbial, antiviral, anti-inflammatory and anticonvulsant properties because of these wide spectrum biological properties. Thiazolidinones are called as molecule of magic. In the recent years, a number of innovative synthetic techniques have been developed to create a variety of scaffolds to investigate a range of biological activities. Numerous researchers have been drawn to this skeleton by the variety in the biological response profile to investigate its potential against various activities.

**Keywords:** thiazolidinones, synthesis, biological activities, thiazolidinone scaffold, pharmacological properties
