**2.7 Fe(II) and Fe(III) complexes**

α-N-heterocyclic thiosemicarbazone and its complex of Fe(III) Anti-cancer activity was studied against human breast cancer cell lines, cervical cancer cell lines and liver cell lines. The results show that iron complex has better activity than its ligand. This study also evaluates the anti-cancer mechanism [70]. 2-Acetylpyridine thiosemicarbazones and its Fe(III) complexes Antiproliferative property were reported. The structure and activity relationship was determined [71]. 2-Acetylpyridine *N,N*dimethylthiosemicarbazone; 2-acetyl pyridine *N*-pyrrolidinyl TSC; acetyl pyrazine *N,N*dimethyl TSC; acetyl pyrazine *N*-pyrrolidinyl and acetylpyrazine-N-piperidinyl TSC and its Ga(III), Fe(III) complexes Cytotoxic activity were studied and it was reported that ligands were enhanced by the chelation with Ga(III) while weakens with Fe(III) [72].

Iron and its complexes of Series of Di-2-pyridyl ketone thiosemicarbazones had good antiproliferative activity against the tested tumor cells [73]. 1-Formylisoquinoline thiosemicarbazone; 4-Methyl-5-amino-1-formylisoquinoline TSC and its Fe(II), Fe(III) complexes were active against P 388 lymphocytic leukemia test system in mice (**Figure 6**) [74].
