**4. Conclusions**

From the above discussion it is concluded that in most of the studies the metal complexes show greater cytotoxic activity than the free ligands. In metal complexes most of the researchers found the activity of palladium and platinum complexes than other metal complexes. There is a gap between structure activity relationship between metal complexes and their activity towards specific species. Metal complexes of thiosemicarbazones shows great antiproliferative activity and destroys cell completely. Several derivatives of TSC and its metal complexes such as Pt(II), Pd(II), Cu(II), Fe(II), Ni(II), etc., shows excellent cytotoxic activity.

*Cytotoxic Activity of Schiff Bases and Their Complexes DOI: http://dx.doi.org/10.5772/intechopen.108570*
