**3.1 Animal preparation**

For the investigation, 25 healthy CD1 mice, 8–10 weeks old, and weighing 18–30 g were employed. The animals were given unlimited access to food and water. For the course of the trial, the food and water troughs were replaced daily, and the beddings were also changed every three to five days. They were kept in a room with standard temperature and humidity levels (between 18 and 23°C and 40 and 60%, respectively), as well as a 12/12-hour light/dark cycle.
