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## Meet the editors

Dr. Serban C. Moldoveanu graduated from the University of Bucharest, Romania, with a Ph.D. in chemistry and an MS in mathematics. He held a variety of teaching positions at the University of Bucharest before emigrating to the United States in 1983, where he taught at the University of Georgia, the University of Louisville, and Mercer University. He also has extensive industrial experience working as an analytical chemist. His

research focuses on various aspects of chromatography and sample preparation. He is the author of more than 150 original papers, 12 books, a number of book chapters, and several patents. He is a member of the editorial boards of the *Journal of Analytical Methods in Chemistry* and *Frontiers in Chemistry.*

Dr. Vu Dang Hoang received his Ph.D. in pharmaceutics from the University of Strathclyde, UK, in 2005. He has been lecturing in the Faculty of Analytical Chemistry and Drug Testing at Hanoi University of Pharmacy, Vietnam, since 2007, and became an associate professor in drug quality control in 2015. His expertise is in the physicochemical characterization of topical drug delivery systems and chemometrics-based meth-

ods for the analysis of drugs in pharmaceutical dosage forms and biological fluids. He also researches the integration of the rigor of quantum chemical calculations to gain insight into molecular mechanisms. He has authored more than 50 papers and edited four books on analytical chemistry.

Professor Victor David graduated from the Faculty of Chemistry, Bucharest, Romania. Between 2007 and 2019 he was the head of the Analytical Chemistry Department at the University of Bucharest, where he is now Emeritus Professor. His main field of research is separation science (theory and applications). His list of publications includes six books for Elsevier and ten for Romanian publishing houses, 12 chapters in books and encyclopedias,

and 150 papers in ISI journals. From 2017-2020 he was Associate Editor of the *Journal of Liquid Chromatography and Related Technologies.* Now he is a member of the editorial boards of *Biomedical Chromatography, Molecules, Journal of Chemistry, Journal of Essential Oil-Bearing Plants,* and *Revue Roumaine de Chimie*. He is co-editor of *Analytical Liquid Chromatography – New Perspectives* (IntechOpen, 2022).

### Contents


Preface

Although gas chromatography and chemometrics are both mature fields of analytical chemistry, progress is continually being made in these important fields. New technologies, new methods, and new applications have been frequently reported in peer-reviewed literature, in manufacturer catalogs, and on the internet. A number of

The introductory chapter describes more recent developments in gas chromatography, and also the utility of chemometrics approaches in gas chromatographic analysis. Chapter 2 describes the principle of negative thermal gradient chromatography, the advantages of this technique, and its applicability. Chapter 3 presents the main characteristics and utility of portable gas chromatography/mass spectrometry systems, and discusses some specific applications. Chapter 4 describes various sampling procedures used to make flavor and fragrance samples amenable to gas chromatographic analysis. Chapter 5 discusses various new applications of gas chromatography in the analysis of biotics and xenobiotics, such as volatile compounds of biological origin, components of biological fluids, drug metabolites, and toxicants. Chapter 6 considers the use of conference matrices as an alternative to other types of screening experiments used in chemometrics to separate key variables from those that are unimportant in large sets of influential parameters. Chapter 7 looks at quantitative structure-retention relationship (QSRR) models for liquid chromatography method

The goal of this book is to increase understanding of the subject by including the most recent information described in a unified form by specialists. The book is addressed to a large audience, including analytical chemists in general, either working on applica-

> **Serban C. Moldoveanu** R.J. Reynolds Tobacco Co., Winston-Salem NC, USA

University of Bucharest, Bucharest, Romania

Hanoi University of Pharmacy,

**Vu Dang Hoang**

Hanoi, Vietnam

**Victor David**

such novel aspects are presented in this book.

tions or lecturing in analytical chemistry.

development.
