**Acknowledgement**

The authors declare no conflict of interest for this work.

We are grateful for fruitful discussions with Drs. Michio Suzuki, Tsutomu Takahashi and Kodai Tanaka.

This work was supported by Health and Labour Sciences Research Grants from Comprehensive Research on Disability, Health and Welfare, Grants-in—Aid for Scientific Research from the Japanese Society for the Promotion of Science, SENSHIN Medical Research Foundation, and Takeda Scientific Foundation.
