**3. Conclusion**

Thus, since the mechanisms of the formation of perinatal-period pathologies in children born prematurely have not yet been fully studied, early and late prevention of most diseases associated with the period of intrauterine development is not possible. However, problems of intrauterine development lie in the genesis of many diseases that appear in later development. Endothelial function is the basis of the formation mechanisms of the immune response to the inflammatory process in the fetoplacental system. Not only in the intrauterine period, but also in the early adaptation period after birth, due to the influence of various exogenous and endogenous factors, changes in the vasoregulatory and inflammatory response of the vascular endothelium affect the manifestation of diseases that appear in later development to one degree or another. Given the nature of the relationship between the inflammatory markers of individual organs and systems and the indicators of endothelial dysfunction, it is not possible to determine the perinatal risk factors affecting the future development of the body, but a wide range of scientific research is being conducted in this direction. Investigating the influence of the level of perinatal organ and endothelial dysfunction markers on further development, as well as the regional characteristics of premature birth, can be the basis for creating a perinatal prevention program for early-age pathologies.
