**3.7 Sticky bone (concentrated growth factors enriched bone graft matrix)**

Sticky bone is a mixture of autologous fibrin glue and bone grafts (autografts, xenografts, allografts) [25]. Sticky bone is also known as a mineralized plasmatic matrix [26–38]. A bone graft obtained in this way is gelatinous in structure, which renders it for shaping. It is rich in growth factors, thereby accelerating tissue regeneration [39, 40]. It has many indications in oral and periodontal surgery as well as in implantology.

Sticky bone can be prepared by using PRP, PRGF, and i-PRF. All these formulations are in a liquid state and are prepared according to different protocols. They differ in their activation mechanisms—transformation to activated platelet gel. To summarize, when in a liquid state, they mix with bone particles or grafts and upon activation they transform to a gel-like state, hence leaving us with a gelatinous mass that we can further shape.

#### **Figure 4.**

*Modernized ALB-PRF protocol. (A) Blood sampling into PET tubes. (B) BIO-PRF centrifuge set on rcf of 700 g for 8 min. (C) Bio-Cool and Bio-Heat device. (D) Syringes with ALB-gel. (E) ALB-gel in a bowl. (F) C-PRFbuffy coat. (G) Immediately after pouring C-PRF into cooled ALB-gel. (H) ALB-PRF membrane.*

*3.7.1 Different sticky bone preparation protocols*
