**2. Epidemiology**

A diabetic person may have a 25% lifetime risk of developing a foot ulcer and diabetes, and patients experience lower limb amputations 15 times more frequently than non-diabetics. Diabetic foot ulcer had a 6.3% global prevalence, with type 2 diabetes having a higher prevalence than type 1 diabetes (6.4 and 5.5%), respectively. The country with the highest prevalence is Belgium (14.8%), followed by Canada and the US (13.0%). Of all the continents, North America has the highest frequency (13%) by far. Asia accounted for 5.5%, Europe for 5.1%, and Africa for 7.2% [12].

*Targeting Matrix Metallopeptidase 9 (MMP-9) and Role of Quorum Sensing (QS) in Diabetic… DOI: http://dx.doi.org/10.5772/intechopen.106514*

From different parts of Ethiopia, Addis Abeba, Jimma, Gondar, Bahir Dar, Mekele, Arbeminch, and Dessie have higher rates of diabetic foot ulcers than other major cities (1.36%, 25.76%, 13.62%, 21.22%, 12.28%, 14.87%, and 1.85%, respectively), according to a study by Tolossa et al. [13] and Degu et al [6].
