*5.3.1 Transcutaneous oxygen tension (Tcpo2)*

Transcutaneous oxygen tension (TcPO2) measurement is an established method of evaluating the cutaneous perfusion and it is also more sensitive in detecting Peripheral artery disease than Ankle brachial pressure index in patients with Diabetes [38]. TcPO2 measures the transfer of oxygen molecules to the skin surface and a reduction in transcutaneous oxygen tension is commonly in patients with Peripheral artery disease [39]. TcPO2 values may be paradoxically increased in patients with Diabetes due to arteriolar shunting in the microcirculation and is also affected by the metabolic demands of the tissue being assessed.
