**4. Conclusions**

DFU frequently results in complications such as infection, osteomyelitis, abscesses and amputations of the lower extremities. It also has a significant influence on patients' physical, psychological, social and economic elements, as well as their overall quality of life. The pathophysiology of DFU, on the other hand, is still unknown. It is critical to understand the pathophysiology of DFU in order to properly treat and manage the condition. Several causes, including diabetic peripheral neuropathy (DPN), which affects 50% of all diabetics, peripheral vascular disease (PVD) and trauma and infection, have been identified as critical events for DFU to develop. Many biological therapeutic remedies have been produced as a result of technical advances to help in the healing process of DFU. Tissue engineering is a revolutionary therapy for DFU that has the potential to lead to new treatments in the future.
