**Acknowledgements**

We appreciate the help from Dr. Xiangwei Xiao from Children's Hospital of Pittsburgh, USA, for his critical advice and proofreading during the preparation of this book chapter. This work was supported by grants from the National Natural Science Foundation of China (NO: 81860153 and 81500589), Key Project of Natural Science Foundation of Jiangxi Province (NO: 20202ACBL216007), Key project of Jiangxi Provincial Department of Education (NO: GJJ180021), all awarded to Dr. Lingyan Zhu.
