*1.2.4 Immunopathy*

Patients with type 2 diabetes have a significantly compromised immune system compared to otherwise healthy people. Diabetic foot infection is therefore a limb-threatening and debilitating disease. Increased blood glucose increases polymorphonuclear cell functions and hampers pro-inflammatory cytokines such as chemotaxis, adherence, phagocytosis, and intracellular killing [13]. The immune system is jeopardized by decreased leukocyte activity, an inappropriate inflammatory response, and disruption of cellular immunity [14].
