**Abstract**

The implications of prolonged hyperglycaemia in diabetic individuals include an increased incidence of foot ulcers. Prolonged hyperglycaemia creates a toxic environment in diabetes nerves, particularly at the foot. It also contributes to the hypoxic situation in this region. This disorder causes the nerves, particularly those in the foot, to die and become incapable of responding to sensation stimuli. However, the pathogenesis of diabetic foot ulcers is largely unknown. This chapter attempts to describe the aetiology of foot ulcers through peripheral neuropathy, vascular disease, trauma and infection and explore the evaluation and diagnostic criteria and the current therapy and management of diabetic foot ulcers.

**Keywords:** hyperglycaemia, diabetic foot ulcer, neuropathy, vascular disease, trauma and infection
