**5. Conclusion**

DFU is a common complication in diabetic patients, and remains a major cause of morbidity in patients with DKD. It has a complex pathophysiology involving a host of metabolic and hemodynamic processes such as diabetic peripheral neuropathy, ischemia (due to diabetic vascular disease) and infections. DFU deteriorates into gangrenes and necrotic wounds when left untreated or when not adequately attended to. Due to its complexity, a team of healthcare professionals are needed in the management of foot ulcerations involving both pharmacological and non-pharmacological interventions to address all three contributing pathologies (neuropathy, ischemia and infection). In some extraordinary cases, surgery maybe needed to provide revascularization, off-loading to relieve high-pressure areas and ultimately relief to patients. As there is significant renal contribution to DFU development and progression, preventive measures should include the need to institute chiropody programs at all dialysis centers to reduce the burden of DFU on dialysis patients, healthcare system and society.

*Diabetic Foot - Recent Advances*
