**4. Issues with the present diabetic foot ulcer treatment**

The primary treatment problems associated with diabetic foot ulcer are believed to be diabetic foot infections and delayed wound healing [25]. The idea of probiotic consumption is intriguing and significant in light of the growing concerns about antimicrobial drug resistance around the world because probiotics have the ability to strengthen the immune system and have anti-inflammatory properties, which may speed up the healing process after a wound [26]. World Health Organization estimates that 60% of microorganisms are developing resistance to important antibiotics and that all diseases will eventually develop 100% treatment resistance. Self-medication as well as ongoing administration of antibiotics could be one explanation for bacteria's increasing tolerance to them. Thorough study is still being done to find new ways to cure disorders brought on by these bacteria [27]. Probiotics and phage therapy are innovative techniques that can eliminate unwanted germs and possibly speed up the healing process [28].
