**2.5 Hormone AL regulation**

In healthy children, statured growth is controlled by the action of circulating hormones. On skeletal system, GH and thyroid hormone (T4) are the major determinants of growth rate during the childhood [38]. They are working synergistically. T4 is predominantly required for skeletal maturation and GH for linear growth. While growth sprout and skeletal maturation of adolescent are primarily depending on gonad steroid in conjunction with GH and T4. Insulin and glucocorticiods influence carbohydrate, fat and protein metabolism, which provides sources of energy needed for growth and exerts a permissive influence on anabolic action of GH [39].
