**6. Pathophysiology of occurrence of SJS/TEN**


#### **6.1 Histopathologic features**

Histopathologic features in SJS/TEN show apoptotic keratinocytes present individually and in clusters within the epidermis. It may also show dendritic cell infiltration, spongiform superficial epidermal pustules, edema of the papillary dermis, and perivascular infiltrates of lymphocytes (**Figure 5**). Subtle vacuolar changes along the basal layer are accompanied by minimal inflammation with scattered lymphocytes within the epidermis [28].

#### **Figure 5.**

*Histopathologic features in SJS/TEN show apoptotic keratinocytes present individually and in clusters within the epidermis.*
