**Acknowledgements**

We would like to thank to the generous support of European Research Council's Horizon 2020 programme under grant agreement 760331 (Newcotiana) and 774078 (Pharma Factory), as well as the Sir Joseph Hotung Charitable Settlement. We also would like to thank colleagues in the Hotung Molecular Immunology Unit at St. George's, University of London for their support and constructive discussion.

*Immunosuppression and Immunomodulation*
