**Abstract**

Healthy operation of every organ depends on immune cells. T-cells, B-cells, and natural killer cells that control the immune homeostasis. Immunotherapy includes the process by which immune cells are immunomodulated. Immunological responses can be induced by immunostimulants, amplified by immune boosters, attenuated by immunomodulators, and prevented by immunosuppressive agents, according to therapeutic techniques. The over-activation of the immune system is mostly to blame for the rise of chronic immunological illnesses such as viral infections, allergies, and cancer. Immunomodulators may also be used to control the severity of long-term immunological diseases. Additionally, it is discovered that these immunomodulatoracting proteins represent prospective molecular targets for the control of the immune system. Furthermore, it is well known that organic molecules like phytocompounds have the ability to bind to these locations and affect the immune system. Curcumin, quercetin, stilbenes, flavonoids, and lignans are examples of specific phytocompounds shown to have immunomodulatory properties to address immunological diseases.

**Keywords:** autoimmune diseases, herbal compounds, immune system, immunotherapy, phytomedicines
