**3. Conclusions**

The role of DCs in malaria infection failed to understand the immunopathology due to several factors in-and-out of experiments. Similarly, the studies which had a focus on direct interaction between *Plasmodium* species and DCs have used human monocyte-derived DCs (moDCs) due to their easy *ex-vivo* generation. However, recent studies have confirmed that moDCs are distinct from blood and cDCs populations and may not represent the true DCs population. Additionally, it has been also hypothesized that inflammatory moDCs are similar to the macrophages and not *bonafide* population of DCs. Further, the relationship between pRBCs and moDCs for their inhibition or activation and how particular stimuli play a cascade role in it is still elusive. Therefore, understanding how malaria infection modulates DCs functions followed by their suppression is not fully studied. Also, whether it can happen directly through interaction with DCs or the involvement of other mediators such as cytokines or metabolites play a crucial role warrants further detailed investigations.
