Meet the editor

Dr. Iavor K. Vladimirov is the founder and medical director of the Sofia IVF clinic (SBALAGRM-SOFIA). He is an honorary lecturer at "St. Kliment Ohridski" University, Bulgaria. Dr. Vladimirov is one of the authors of "Theory about the Embryo Cryo-Treatment," which is the first theory giving a scientific explanation for the high success rate in some infertility cases using the embryo freezing and thawing procedure. He has

introduced the following methods in Bulgaria: assessment of the ovarian reserve, in vitro maturation, and determination of the so-called implantation window using endometrial receptivity analysis (ERA). He is a member of numerous professional and scientific organizations relating to the problem of infertility and has received various prestigious awards and accolades.

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Preface

More than 45 years have passed since the successful application of in vitro fertilization (IVF) technologies and the birth of the world's first baby. Over the past few decades, assisted reproductive technologies (ARTs) have become one of the fastest-growing branches of medicine, with IVF becoming the main approach to treating infertility.

Numerous significant discoveries and improvements have helped increase the effectiveness of IVF technology such as the intracytoplasmic sperm injection (ICSI) procedure and the freezing of gametes, embryos, and reproductive tissue via vitrification. These innovations aim to increase the success rate of fertilization and reduce patient risk and service costs. They have led to the optimization of some phases of the treatment process, such as the development and implementation of stimulation protocols to reduce patient risk and innovations in the IVF laboratory to establish the embryo with the greatest potential for implantation and the birth of a healthy baby. At the heart of this approach is the thesis, which I follow, that each and every embryo is a living organism, not a group of cells, for which we must take care, creating optimal conditions for its development and treating it as needed, as we do for our patients.

This book focuses on the application of various methods and techniques for the diagnosis and treatment of infertility through IVF technologies. The authors consider topics such as sperm analysis and new modern diagnostic approaches, clinical and laboratory aspects of the in vitro maturation method, oocyte freezing, as well as the quality management system in assisted reproduction, in accordance with modern European standards. The book also discusses topics such as immunology and infertility and artificial intelligence in ovarian stimulation. Finally, it examines ovarian reproductive aging and rejuvenation strategies, the new challenge in the treatment of

This book is a useful resource for embryologists and physicians concerned with the

**Iavor K. Vladimirov**

Sofia, Bulgaria

IVF Clinic (SBALAGRM-SOFIA),

diagnosis and treatment of infertility through in vitro technologies.

infertility through IVF technologies.
