**6.2 Ginger's anti-epileptic properties**

Ginger has been shown to have extraordinary effects on epilepsy patients who suffer from recurring seizures. When compared to younger individuals, epilepsy in the elderly has fewer pre-symptoms and a longer duration of postictal disorientation [70–72]. This effect could be linked to the substantial changes in brain anatomy that occur as a result of ventricular expansion speeding up as people get older [73]. Ginger extract was effective for reducing the duration and incidence of seizures induced by pentylenetetrazole (PTZ), which is a well-known inducer of epilepsy-like symptoms in an age-dependent manner [74, 75]. Another study conducted lately in mice found comparable benefits after treatment with ginger extract [76]. Ginger therapy significantly reduced myoclonic and clonic seizures, as well as forelimb tonic extension, in both investigations. These effects of ginger could be attributed to 6-gingerol's inhibitory effects on the synthesis of nitric oxide (NO), which activates the soluble guanylyl cyclase, which controls the seizure threshold [77].
