**4. Curcumin-loaded nanoparticles**

Nanoparticles (NPs) have improved the main drawbacks associated with the use of curcumin in biomedical applications, these shortcomings include its rapid metabolism, low solubility, and poor bioavailability, which are considered major

obstacles for the treatment of cancer [119], wound healing [120], Alzheimer's disease [121], epilepsy [122] ischemia [123], and inflammatory diseases [124]. The delivery of therapeutic concentrations of curcumin using nanoparticles is emerging as one of the most useful alternatives to treat different diseases including cancer and microbial infections (**Figure 3**). **Table 3** summarizes the therapeutic potential of curcuminloaded nanoparticles on different diseases.
