*Chitosan-Based Nanocomposites for Biological Applications DOI: http://dx.doi.org/10.5772/intechopen.106379*

advantages and disadvantages of controlled release systems can be summarized as follows [25, 32–42]. Advantages of controlled-release systems:


Despite all these benefits, there are still unsolved problems with controlled release systems. Main disadvantages:


In some of these systems, the cost may be greater than in conventional dosage forms. However, well-designed controlled release systems are preferred because they reduce overall health expenditures when evaluated in terms of cost-effectiveness. Controlled release systems of cancer, hormone, enzyme, antibiotic, antirheumatic drugs, and some existing drugs produced in biotechnology or classical technologies have been prepared. Thanks to the developments in molecular medicine in recent years, controlled release systems have also given successful results in the use of protein and peptide drugs.
