**2. Final comments**

Like other scientific disciplines, chemistry is in full growth. The twenty-first century already registers a variety of relevant topics that present an extraordinary development. In this sense, the International Union of Pure and Applied Chemistry recently carried out an analysis of the most promising emerging fields of today (**Table 2**) [12]. Asymmetric organocatalysis and mechanochemistry stand out in this list, of which the first has just been recognized with the Nobel Prize in Chemistry 2021 awarded to Benjamin List and David MacMillan. During the last two decades diverse experimental protocols have made organocatalysis an even "greener" alternative by the use of friendlier reaction conditions, or via the application of solvent-free methodologies activated by mechanochemistry. Alternative strategies include the design and synthesis of more selective catalysts, or via the development of multicomponent one-pot organocatalytic reactions, or by the recycling and reuse of organocatalysts, or by means of the application of more energy-efficient activation techniques, among other approaches. It is reasonable to expect that Green Chemistry, including the field of mechanochemistry, will also be recognized by the Nobel Prize committee in the near future.

#### **Table 2.**

*IUPAC announces the top ten emerging technologies in chemistry [12].*
