**8. Conclusion**

This review shows the importance of degrading lignin, specifically in the bleaching process in the paper industry, since highly harmful pollutants are generated, thus affecting the environment and human health. Furthermore, other persistent organic pollutants (POPs), which are related to pesticides, drugs, dyes, etc., produced and wasted in other industrial process, are also on big concern. The toxicity of all of these POPs particularly organochlorines tends to increase according to the degree of chlorination turning them more resilient and produce biomagnification, because accumulate in adipose tissue on different animals including human beings from where is distributed through blood at different organs and tissues giving concentrations higher than those of the environment with the potential to cause diseases such as cancer and reproductive defects. However, exist different strategies to remove and reduce them in the environment but need to be

improved. Within these strategies, exist the biological methods particularly filamentous fungi, bacteria, and yeasts, with potential to degrade lignin and several POPs thanks to the synthesis and secretion of extracellular enzymes as LiP, MnP, Lac, and VP than depolymerize and transform POPs in nontoxic compounds. These methods are friendly to the environment, they are less expensive, compared to the physical-chemical ones.
