**Abstract**

Chronic pain is one of the most complex clinical conditions to manage, it can affect approximately 20% of the population and has a high economic cost. In recent years, the voltage-gated sodium channel Nav1.7 has been proposed as a therapeutic target against pain due to the evidence that certain mutations in the gene that encodes it can cause chronic pain or the absence of this dependent nature. Several molecules have been discovered - both synthetic and natural - that seek to selectively inhibit Nav1.7 in the search of an effective treatment without side effects against chronic pain.

**Keywords:** sodium channel, Nav1.7, pain, analgesic
