**Abstract**

Breast cancer is the most common type of cancer and causes the highest mortality in women worldwide. The triple-negative breast cancer (TNBC) subtype is present in 15–20% of women with breast cancer, and it does not have estrogen receptors, progesterone receptor or HER2. It occurs in young, Hispanic, African-American women, characterized by worse prognosis, high recurrence and metastasis, and has limited treatment options. Integrins are heterodimeric transmembrane receptors involved in cancer by regulating angiogenesis, proliferation, migration, cell invasion and metastasis. Disintegrins are small proteins (4–14 kDa) localized in snake venom capable of interacting and interfering with the activity of integrins involved in cancer. There is an urgent need to provide therapeutic alternatives for breast cancer. In this review, we present the *in vitro* and *in vivo* effects of disintegrins that have proven their effect in breast cancer.

**Keywords:** breast cancer, disintegrins, integrins, triple-negative breast cancer, venom snakes
