**5.2 Inclusion and exclusion criteria**

Inclusion criteria were based on the following: 1. Locating studies of disintegrins with activity in breast cancer; 2. that used the MCF-7, MDA-MB-231 cell line and human cell primary culture; 3. that were written in English. The exclusion criteria were: 1. that the disintegrins were not ADAM; 2. that they evaluated only the MDA-MB-435 or murine breast cancer cell line (66.3p); 3. that they did not evaluate the anticancer activity; 4. that the publications were not written in English due to not having suitable tools to perform a faithful translation.

*A Systematic Review of the Pharmacological Potential of Disintegrins on Breast Cancer DOI: http://dx.doi.org/10.5772/intechopen.105162*

#### **5.3 Data extraction and analysis**

The data were analyzed by two reviewers (ALP and IVB). The descriptive variables taken were type of disintegrin, cell line, the effect *in vitro* and effects *in vivo.*

### **5.4 Selection of studies**

The papers identified with the term Mesh: "Neoplasms Disintegrins" yielded 152 publications. We decided to add one article that included human breast cancer primary cultures. The final analysis was 9 articles after applying the inclusion and exclusion criteria described above.

