*3.1.3.2 BDNF and FGF2*

Another astrocyte secretory factor that is involved in adult neurogenesis is BDNF. Astrocytes regulate the removal and recycling of pro-BDNF [77]. Pro-BDNF neuronal precursors are taken up by astrocytes through endocytosis and then converted to adult BDNF. Overexpression of BDNF-containing hippocampal astrocytes promotes the survival and maturation of abGCs and was associated with an anxiolytic/antidepressant-like effect in mice [78]. The process of neurogenesis is also supported by FGF-2, which is mainly produced by astrocytes. In addition, astrocyte-derived FGF-2 facilitates abGC differentiation and function [73].
