**10. Conclusion**

Astrocytes play a significant role in the homeostasis of the central nervous system. Astrocytic cells are central homeostatic and protective cells of the nerves. The decline

*Impact of Hypoxia on Astrocyte Induced Pathogenesis DOI: http://dx.doi.org/10.5772/intechopen.106263*

in nerve cells or astrocytes causes a disease-permissive landscape and triggers nerve cell malfunction, nerve cell death, and nerve cell deficiency. Astroglial atrophy is mainly noticeable in major psychiatric illnesses. Severe reactive astrogliosis and glial scar formation at the location of the neurons trauma are glowing familiar to inhibit axonal regeneration. More research into the processes of Astrocytes protection, particularly the substances they produce, will give crucial insights into how to protect the Blood–Brain Barrier throughout trauma and neurological condition.

Moreover, its expression timing in astrocytes is essential to determine the influence of hypoxia-induced signalling on stroke volume. Furthermore, in addition to the impacts of hypoxia-signalling in astrocytes on neuron viability, it seems necessary to consider how such alterations will affect astrocyte viability. We must fully comprehend how to lessen the harm caused by stroke if we can better define the various consequences of hypoxia signalling in astrocytes.
