**7. Therapeutic aspects**

Nowadays, there is not an effective treatment for exclusively the absence or the excess of forgetting. There are two possibilities for therapeutic goals: using drugs and not using them. In the first one, all the strategies to avoid forgetting. At this point, it can be used all the drugs involved in the treatment of dementia. Although how it was explained, the mechanism of action is not the same, because in amnesia there is clear damage to neurons, in forgetting not. All the cholinesterase inhibitors like donepezil [57], rivastigmine, or galantamine [58]; glutamate regulators like memantine [59]; or more recently, with the use of monoclonal antibodies treatment like aducanumab could be considered [60], all the studies published in 2022. It is desirable the use of cognitive-behavioral psychotherapy using strategies and exercises to promote memory.

It exists also the use of neuromodulation to promote memory in patients with Alzheimer's disease (AD) [61]. It is still an experimental tool for this proposal. The main target is Deep Brain Stimulation (DBS) to avoid amnesia. The use of DBS could improve the fall of memory centered in the fornix of patients with AD [62, 63]. Not forgetting (how it is considered in this chapter) has already been evaluated.

On the other hand, there are no punctual drugs to increment forgetting. In patients with depression or anxiety, the treatment is focused on its disease, like antidepressants or anxiolytics. Insomnia patients could use anxiolytics. Also, specific medications, like suvorexant, a drug that acts in the orexin neurotransmitter in the hypothalamus to regulate the sleep-arousal cycle, according to Rahman in 2022 [64].

There is no choice to improve forgetfulness in a precise manner, as DBS does with AD patients. It must be explored this area, thinking in a brain surgical target: a list of possible targets is each part of the verbal memory, like the hippocampus, fornix, or amygdala. It could be considered, and indeed, they are used with DBS in patients with epilepsy, aggressiveness, or AD.

Depressive or anxious patients could be treated with Transcranial Magnetic Stimulation (TMS) to diminish the symptoms [65, 66]. Also, it is possible for future protocols to evaluate forgetfulness.
