**2. Anatomical association**

Astrocytes tile the whole CNS in a touching, non-covering, organized, and efficient way. Comparative individual astrocyte areas show up liable to exist in white matter. However, this has not yet been as broadly written about. Astrocytes are giant, intricate, and different from astrocytes in rodents. Astrocytes show controlled proliferation in intracellular calcium absorption [Ca++], which signifies a method of astrocyte excitability. An enormous suggestion is now obtainable that these delimited proliferations in astrocyte [Ca++] remain of purposeful importance in astrocyte and astrocyte-neuron intercellular communication. The advice is that calcium signalling permits astrocytes to show a direct role in synaptic transmission. It's worth noting that astrocytes do communicate with one another via gap junctions generated by connexins. Gap junctional partnering of astrocytes into multicellular systems may contribute to normal function and CNS disorders. The suggestion is that calcium signalling permits astrocytes to show a natural interest in synaptic transmission.

*Impact of Hypoxia on Astrocyte Induced Pathogenesis DOI: http://dx.doi.org/10.5772/intechopen.106263*
