**2.8 Autoantibodies against epithelial cell adhesion molecules**

In a study examining eosinophilic esophagitis (EoE) patients, Dellon detected higher levels of anti-DSG3 IgG4 in EoE patients' serum compared to healthy controls (p = 0.02). In addition to that marker, he also detected very high levels of Anti-NC16A IgG4 EoE patient's serum when compared with healthy controls (p < .001), which then led him to conclude that this marker is useful for diagnostic utility as a serumbased EoE biomarker [61].
