*5.1.2.2 Symptomatology*

Among the most widely used methods to assess the presence of gastrointestinal symptoms in patients with CD is the Gastrointestinal Symptom Rating Scale (GSRS) questionnaire [79, 80]. This questionnaire serves to check symptoms and determine the improvement and evolution of CD. However, there are a large number of patients with CD who are asymptomatic or minimally symptomatic at the time of presentation and, in these cases, it would not be feasible to use the clinical response as an indicator of intestinal mucosal recovery and adherence to GFD [13, 70].
