**7. Conclusions**

To conclude, GI autoimmune diseases can be compromising to the patients' life, and they can be due to multiple factors. Over the past few decades, the number of GI autoimmune diseases have increased exponentially. GI autoimmune diseases although they are organ specific. Nevertheless, there is a need for multidisciplinary approaches for diagnosing and understanding the pathogenesis of these diseases. Antibodies provide a current excellent predictor for those diseases. Nevertheless, the investment in biotechnology to develop more specific and sensitive tools for is needed. The understanding of the interwinding between the brain and gut as well as other etiological factors can provide better approach in preventive medicine in dealing with this disease as well as increase in the quality of the life of the patients beside the current available pharmacological and surgical available options.
