**10. Miscellaneous bacteria and gallbladder cancer**

Gene fragments of *Collibacillus*, *B. fragilis*, *Klebsiella*, *C. perfringens* and *Clostridium* spp. have been identified in the bile and gallbladder tissue of patients with GBC [134]. A positive correlation between the bacterial species of *E. coli*, *E. fecalis*, *Klebsiella*, and *Enterobacter spp. B10* along with *Peptostreptococcus stomatis*, *Fusobacterium*, *Firmicutes nucleatum*, and *Enterococcus faecium* with the development



*Role of Gut Microbiome and Enteric Bacteria in Gallbladder Cancer DOI: http://dx.doi.org/10.5772/intechopen.104404*

**Table 1.**

*Studies show the association of the gut microbiome with gallbladder cancer.*

of GBC has also been found in recent studies [135–137]. These bacteria were commensals of the gut and have been associated with colorectal cancer [138], gastric cancer [139], and metastatic melanoma [140]. Thus, their presence in gallbladder tissue and bile may indicate their association with GBC. **Table 1** summarizes the various studies showing an association of gut microbiota with GBC.
