*5.1.1 Experimental studies*

The experimental results argue for the interference of the microbiota and T1DM pathological mechanisms—the incidence of diabetes is higher in mice raised in aseptic conditions, and the antibiotics administered to conventional animals accelerate the evolution of diabetic pathology. The NOD (non-obese diabetes) mice have a distinct microbiota from other resistant lines, and the incidence of type 1 diabetes mellitus is higher in specific pathogen-free animals [70].
