**3. Clinical manifestations**

Clinical characteristics of CD differ considerably depending on the age of presentation, and it can also be profuse or simply present analytical abnormalities [33–36]. It can manifest clinically with a wide variety of symptoms that affect multiple organs and systems and that can be both gastrointestinal (diarrhea, vomiting, abdominal pain, bloating, bloating, constipation, gastroesophageal reflux, among others) and extra-intestinal (tiredness, dermatitis herpetiformis, anemia, osteoporosis, infertility, growth retardation, neuropathy, ataxia, delayed puberty, etc.) [8, 25]. Symptomatic

CD can be classified into classic and non-classic. Any case presenting with malabsorption is classified as a classic CD. Although the clinical presentation is changing toward an affectation of older individuals with milder symptoms. The symptomatic classical disease was previously the most common presentation, and although it remains a prominent mode of presentation, subclinical and nonclassical cases now make up roughly 30% and 40–60% of new cases, respectively [37, 38].
