*4.1.3 Atherosclerotic cardiovascular disease (ASCVD)*

In 12,976 patients with ASCVD from the American health insurance database, ≥80% adherence to both statins and ACEIs reduced the risk of long-term MACEs than <40% adherence (8.42% vs. 17.17%, HR 0.56, *P* < 0.0001) and 40–79% adherence (8.42% vs. 12.18%, HR 0.76, *P* < 0.0001) at 2 years [42]. Consistent with this finding, another study in 185,252 patients with ASCVD from the Taiwan National Health Insurance database found that ≥80% adherence to statins reduced the risk of ASCVD-related secondary rehospitalization (aHR 0.90, 95% CI 0.87–0.92, *P* < 0.05) and in-hospital death (aHR 0.59, 95%CI 0.53–0.65, *P* < 0.05) [44].
