**3.2 Indirect mechanism of cancer-associated thrombosis**

Indirect mechanism also promotes thrombosis events in cancer patients. Tumoral cells can synthesis and secrete numerous thrombogenic inflammatory cytokines which lead to the expression of specific adhesion molecules on surface of endothelial cells and monocytes, so cause activation of endothelial cells and procoagulant properties [9, 13, 14] (**Figure 1**).
