**16. PTPN22 and SLE**

Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a negative regulator of T cell activation associated with several autoimmune diseases and SLE. In individuals of European ancestry, The rs2476601 is the most significantly with SLE associated polymorphism expressed at higher levels on T cells from patients with lupus contributing to SLE pathophysiology [27, 28].
