**13. PPP2CA gene and SLE**

The protein phosphatase PP2A consists of three subunits but evidence reveals only the involvement of the catalytic subunit PP2Ac in the pathogenesis of SLE. PP2A controls various cellular pathways including DNA replication, gene translation and cell differentiation. The enzymatic activity of thePP2Ac is augmented in SLE. PP2Ac is dysregulated in SLE, resulting in altered transcription factor activation in T cells that affects their function by decreasing their capacity to produce IL-2 and reducing their expression of the T cell receptor (TCR) associated signaling molecule CD3ζ [27].
