**Abstract**

The desire for pregnancy in patients with systemic lupus erythematosus (SLE), which was previously considered a potentially lethal enemy for the mother and the product, today is part of the success of advances in the treatment and control of the disease. In this chapter, we will talk a little about the pathophysiology of the pregnancy of the patient with lupus, going through the relationship with the treatments received, and the way in which these can directly affect fertility and pregnancy. We will also briefly comment on the compromise of the product in the case of neonatal lupus, and if it really has to do indirectly or directly with the existence of SLE in the mother. We will address pregnancy-related complications along with biomarkers and clinical signs that could indicate inherent risks already widely known in the literature.

**Keywords:** lupus nephritis, contraception, neonatal lupus, abortion, antiphospholipid syndrome, relapse, hydroxychloroquine, preeclampsia, hypertensive disorders of pregnancy, proteinuria
