**1. Introduction**

Talking about lupus without talking about the reproductive probability of women is impossible. They go hand in hand, first because the disease is more common in patients of childbearing age, and because in the past pregnancy was an absolute contraindication. In current time a normal pregnancy we can achieve it as possible and also its activity since it plays an important role in the occurrence of relapses and therefore complications that generate morbidity and mortality in both mother and fetus. In this chapter, we are going to talk about a "deck" of possibilities of existing complications in the mother, also something about anti-inflammatory drugs and their use in pregnant patients and superficially direct effects of the disease on the product.

Currently, all processes related to reproductive health, such as contraception and stricter control of pregnancy, are more frequent for patients with good results in most cases, but without neglecting the fact that pregnancy continues to be associated with greater maternal morbidity and mortality and fetal. When reviewing the literature and in daily practice, we find that the persistence of activity in pregnancy has been directly related to estrogen levels. This "time bomb" triggers maternal, pregnancyrelated, and fetal complications. In the case of the mothers, lupus outbreaks, with important compromises in target organs (brain, kidney, vascular, placenta, and

lung). Obstetric complications (fetal loss, intrauterine growth retardation, and premature birth) and their incidence increase when it is related to anti-phospholipid antibody syndrome and in the newborn indirectly cases of neonatal lupus due to the transplacental passage of antiantibodies [anti-Sjogren's syndrome A (SSA) or anti-Sjogren's syndrome B (SSB)] [1]. Unquestionably, for a good outcome and development of these pregnancies, preconception counseling must be strictly followed, plus multidisciplinary management by a rheumatologist, gynecologist or perinatologist, nutritionist, and psychologist. The primary objective to achieve success in pregnancy and the reduction of complications is mainly that there is no lupus activity in at least 6 months, with an adequate prescription of medications that are safe in pregnancy, always taking into account clearly the patients and their risk factors, and mandatory regular follow-up [2].
