**6.3 Hematopoietic stem cell transplantation (HSCT)**

Hematopoietic stem cell transplantation (HSCT) can normalize abnormal hemostatic derangement in β-thalassemia patients by increasing natural anticoagulant proteins and activating platelets in the circulation and reducing microparticles and Exposure of abnormal RBCs membrane to PS (results in reduction of normal dissemination of RBC membrane phospholipids) [2].
