**2.3 Temperature**

Waugh and Evans [19] demonstrated that the temperature plays an important role in RBC deformability. Below 25°C, deformability decreases as temperature decreases, whereas no apparent change in RBC deformability is observed between 25 and 37°C [20]. Moreover, body or febril temperature may be particularly important since the increase of body temperature decreases RBCs' elasticity and filterability. However, this has no clinical effect on the pathophysiology of haemolytic anaemia [21].
