**1. Introduction**

Wound occurs mainly because of an injury, burn, surgery, infectious disease, or a pathological condition that leads to a compromise in the overall integrity of the tissue. Wounds are considered as major healthcare challenge affecting several million people globally due to the underlying complications resulting from infections and comorbidities such as diabetes. Lifestyle disorders enhance the risk of complications and lead to improper/delayed wound-healing processes. Despite of thousands of marketed products available to treat wounds, it is still considered as a burden to the individual and to the society at large [1].

Managing wounds is not at all easy, especially due to the various steps involved in the healing process. Most of the healing methods rely on the "tried and tested"

approach, but off-late, there has been a high influx of new products in the market, as well as the latest technologies, to increase the wound repair armamentarium. A vast majority of the new products in the market are refurbished and updated versions of the older ones. Most of the newer wound management products are the result of newer fields of research and investigation. Older wound-healing products, such as plain gauze, are still being extensively used as dressing in hospitals, but better and advanced understanding and novel technologies have resulted in certain products that aid in achieving the ideal moist, protected, and warm wound-healing microenvironment. The bioactive properties such as antimicrobial action and immune modulation create a microenvironment favorable for healing. The current wound care products in the market include alginate, cellulose, chitosan, collagen, and hyaluronic acid.

Nobel laureate Richard Feynman in 1959 first predicted the emergence of a new field of study that deals with structures ranging in the nanoscale. Sixty years later, the impact that nanotechnology has in our lives these days is huge, it is playing a role in important fields such as diagnostics and therapeutics *via* its role in the development of various medical devices [2]. With the rapid growth of nanotechnology as a research field worldwide, a plethora of nanomaterials has garnered importance in the biomedical and healthcare sectors. Several nanotechnology-based products are currently being investigated to aid in wound healing. Owing to their interesting properties at both chemical and physical levels, nanomaterials have gained a lot of attention in research [3]. Nanodevices being innovative provide us with a wide range of benefits such as entry across cellular barriers, nonantigenic, anti-shear stress, and gasexchange permeability, modulation of biocompatibility, and bioavailability of drugs as well as nanodelivery option [4–7]. Nanotherapies lead to improvement of the healthcare sector by enhancement of currently available medical prognosis and treatments for challenges such as impaired wound healing. Despite the development of potential biomaterials and nanotechnology-based applications for wound healing, this scientific knowledge is not translated into an increase of commercially available wound-healing products containing nanomaterials [8].
