**2. Epidemiology**

The incidence of pemphigus group disease is about 1 in 100,000, while PV occurs at a rate of 0.1 to 0.5 per 100,000, with a higher rate in Ashkenazi Jews and people of Mediterranean descent. In India, Malaysia, China and the Middle East, PV accounts for 70% of all pemphigus cases and is the most common autoimmune bullous disease [1].

The average age of onset is between 45- and 65 years. Pemphigus is rare under 18 years of age, except in endemic areas where 30% of patients are reported to be younger than 20 years of age [2]. All over the world, men and women are equally affected. However, adolescent girls are more affected than boys of the same age [3].
