*2.1.5 Cellularity*

Cellular skin substitutes contain viable cells such as keratinocytes or fibroblasts and as such they may incite an immunogenic host response due to antigenicity. These materials are bioengineered from human sources such as Dermagraft (source material: neonatal foreskin). The inclusion of cellularity as a property of skin substitutes was necessary given its implications for wound indications, risk of rejection, cost and regulatory issues.
