*Application of Cell-Based Therapies in Veterinary Dermatology DOI: http://dx.doi.org/10.5772/intechopen.111553*

bioactive substances such as proteins, cytokines, growth factors, antioxidants, proteosomes, and exosomes that interact in an autocrine and paracrine way. MSCs secretome is an alternative therapeutic option and can help solving some limitations related to the use of living cells, such as tumorigenicity, immune compatibility, and infection transmission [10].

Among the numerous performance capabilities of MSCs, it is important to highlight their high capacity to differentiate into various cell types such as osteoblasts, chondrocytes, adipocytes, hepatocytes, myocardial cells, endothelial, neuronal, and epithelial cells, helping in the regeneration of damaged tissues. The potential to secrete cytokines and growth factors can promote angiogenesis and neo-vascularization, thereby increasing tissue blood flow, and the anti-apoptosis characteristics through the production of cellular factors that promote cellular survival prevent apoptosis or programmed cell death. In addition, MSCs can migrate to damaged areas of the body where they can act in tissue repair, which allows its local application directly *in situ* or *via* systemic administration. Their anti-inflammatory action and the inhibition of pro-inflammatory factors, as well as the immunomodulatory potential, make these cells good candidates to the treatment of dermatological disorders, as described in the characteristics in **Figure 2** [3, 14, 17, 18].
