**1. Introduction**

In the last years, regenerative medicine has been developing in fields such as wound healing and skin regeneration. The skin acts as a protective barrier that isolates the body from harmful agents and injuries. In addition, the skin also contributes to homeostatic maintenance, regulating the body's temperature and internal integrity. Age, tumors development, congenital defects, and degenerative diseases are some

of the factors associated with difficulties in wound healing, reason why regenerative medicine can be very helpful in the achieving better results [1]. The skin can be frequently injured because of both chronic and acute wounds (burns, diabetic ulcers, and atopic dermatitis), and these patients experience mental, physical and health constrains that can lead to a huge socioeconomic burden [2]. Recently, MSCs started to be used as therapeutic agents capable of regenerating damaged tissues and organs [3]. For that reason, new cell-based therapies have received attention in both human and veterinary medicine. MSCs are multipotent cells that derive from the embryonic layer of the mesoderm. Besides, under the right *stimulus*, these cells can differentiate into different lineages, such as osteoblasts, myocytes, chondrocytes, among others [3–5]. MSCs are undifferentiated cells with specific characteristics such as selfrenewal capacity, originating cells with identical characteristics, and the potential or ability to differentiate from cells in mature tissues, which gives them the ability to repair tissues and organs [6, 7]. There are numerous clinical studies demonstrating the therapeutic potential of MSCs in various fields of veterinary medicine [3]. Moreover, it is known that conventional treatments, based on medical drugs, are often associated with unwanted side effects due to the re-use of these drugs. Nevertheless, despite the capacity of MSCs in wound repair and cutaneous regeneration, there are some limitations, such as the heterogenicity in the delivery protocols, site of delivery, and the lack of information concerning MSCs functional properties and phenotype [2].

Several dermatological problems have a congenital origin and a chronic/recurring nature, forcing these animals to receive repeated and prolonged drug treatments with the consequent development of side effects. Furthermore, skin diseases require a lot of attention, since they are associated with expensive treatments that are usually ineffective [1]. Studying the use of cells as a therapeutic agent instead of conventional drugs, for the control of these patients with dermatological problems, is therefore of special interest.

This review analyzes the most relevant stem cell types in skin regeneration and specific dermatological that may benefit from treatment with this new therapeutic approach.
