**11. Nanotechnology-driven targeted delivery achieves cell-type specificity**

The field of targeted/site-specific delivery of nanomaterials is still in its young days in comparison to various other nanotechnologies used for wound-healing applications. Targeted delivery of therapeutics is highly recommended and significant to reduce side effects, improve efficacy, and reduce therapy costs [180]. This also overcomes the limitation of a low viable cell number homing the target tissue that has often been associated with systemic stem cell therapy. This platform is highly versatile and can be customized for the targeted delivery of cells, DNA, proteins siRNA, and small drugs, to any target tissue. This is achieved by complexing the NP with the therapeutic agent and with the aid of a molecular recognition molecule integrated within the NP.

Recently, SDF1 was used for targeted delivery to the injury site employing ROS stimulus-responsive polymeric NPs as delivery vehicles [191]. The nanocarriertargeted delivery platform demonstrated high efficiency and biocompatibility to direct SCs to the injured tissues, resulting in enhanced angiogenesis and repair of injury with no toxicity or immunogenicity involved.
