**6.2 Electrostimulation**

While the first exploration of electrical current in skin was described as early as 1860 by DuBois-Reymond; the fact that wounds treated with electrostimulation had a positive potential compared with the surrounding skin was only confirmed in 1945 [64]. It is believed that electro-stimulations aides in wound healing by accelerate the wound-healing process by tissue increasing the migration of vital cells to the site of injury i.e., neutrophils, macrophages [64–66] and fibroblasts [67–69] by imitating the natural electrical current that occurs in skin when it is injured and thereby accelerates the healing process [70–72].
