**10.1 Guidewire cannulation**

Cannulation of the bile duct and pancreatic duct using a guidewire inserted through a catheter has been shown to significantly reduce the incidence of post-ERCP pancreatitis when compared with the conventional contrast cannulation [42–44]. Guidewire cannulation reduces post-ERCP pancreatitis by avoiding hydrostatic injury to the pancreas that may occur contrast injection and by reducing the need for precut sphincterotomy.
