**2. Pathophysiology**

BE reflects chronic chemical inflammation, as a consequence of persistent gastroesophageal reflux. Basically, it is the acidic content of the stomach, bile and small intestines, and pancreas as a potential cause of reflux changes. From this reflux, different cells react, including stem cells that express HOXA13, which are characterized by distal (intestinal) characteristics and compete with normal squamous cells [7].
