**5.2 Baclofen**

Baclofen is currently used off-label for GERD management. It works by stimulating the GABA-B receptor leading to reduced release of glutamate and aspartate and also reduces input into the alpha motor neurons [4]. Baclofen has been shown to reduce transient LES relaxation, reflux episodes, the number of postprandial acids and non-acid reflux events, nocturnal reflux activity, and belching attacks in two short-term randomized controlled trials [4]. Its use in GERD treatment is limited to patients refractory to PPI therapy and has no symptomatic relief [4].
