**3. Diagnosis**

For the diagnosis of GERD and BE, in addition to the relevant clinical data, the macroscopic view during the endoscopy and the microscopic examination after biopsies have been taken are also necessary. In non-dysplastic Barrett's, goblet cells and specialized intestinal cells are characteristic, which have replaced the previous multilayered epithelium. Of course, this is the body's initial protective reaction to the reflux content, but it does not withstand time, following BE with a tendency to fail to turn into adenocarcinoma (**Figures 2** and **3**).
