**8. Conclusion**

NAFLD is the pathological state co-mediated by several stages, involving hepatic FAs uptake, FAs and TG synthesis, hepatic LDs formation, lipid mobilization and degradation, and FAs secretion. Current studies suggest that dietary structure and genetic variants are likely to alter metabolic pathways that lead to the imbalance of hepatic FAs uptake and utilization. There exist complex mechanisms to maintain hepatic lipid homeostasis and prevent chronic lipid overload, which may indicate any intervention on lipid metabolic pathway lead to significant consequences on lipid homeostasis. Therefore, the effect of individual differences on disease occurrence and prognosis need to be awarded in further research and treatment of NAFLD.
