*3.15.7 FGF (Fibroblast growth factors)*

FGF19 is a gastrointestinal hormone that regulates the synthesis of bile acids, the metabolism of glucose, and the oxidation of fatty acids in the liver. FGF19 levels are decreased in NASH patients. Hepatic steatosis and liver enzymes were successfully reduced by the injection of FGF analogs. Another hormone that affects metabolism and energy expenditure is FGF21. Elevated FGF21 levels in NAFLD patients are adversely correlated with reduced insulin sensitivity. High doses of recombinant FGF21 were given to reduce body weight, enhance glucose sensitivity, and change liver and plasma lipid levels [48, 49].
