**6. Hepatic FAs secretion**

Except FAO, non-oxidized FAs in the liver could be esterified into TG and then used for VLDL secretion. During this time, circulating lipids could undergo a series of process, including internalization, procession and incorporation into TG, CE and membrane lipids, and TG secretion, by which hydrophobic FAs are released into the blood stream as the form of VLDL [81]. VLDL is initially formed with the transfer of a apolipoprotein B100 (ApoB100) from the rough to the smooth ER, in which a primordial VLDL particle is form by the addition of TG via microsomal TG transfer protein (MTTP). Then, the nascent VLDL particle is transferred to the Golgi apparatus and further forms a mature VLDL particle [82].

The link has been established between increased VLDL secretion and metabolic diseases [81, 82]. Although studies found that the greater availability of TG and higher MTTP activity could promote VLDL particle production and plasma TG
