**6. ERRs in the development and progression of non-alcoholic steatohepatitis**

NAFLD and NASH are common chronic liver conditions and comorbid diseases for more severe liver disease [86, 87]. Simple fatty liver or steatosis is readily reversible while NASH can progress to more morbid forms of liver pathologies. In subsets of patients, the disease can progress to fibrosis/cirrhosis and liver cancer.

Lipid metabolic dysfunctions in the liver is a key contributing factor to the development of liver steatosis [88, 89]. Depending on the metabolic state, different cellular
