*3.15.1 ACCs inhibitors*

Acetyl-Coa carboxylases (ACCs) promote de novo lipogenesis through the conversion of Acetyl-CoA to Malonyl-CoA, which is a signaling molecule that suppresses fatty acid oxidation. Thus, ACC inhibition reduces lipid accumulation in the liver and stimulates fatty acid oxidation, improving hepatic steatosis and insulin sensitivity in studies in animal models and humans. The problem that arises, is that it also causes hypertriglyceridemia which may further worsen NAFLD [43].
