*3.15.2 FAS inhibitors*

Malonyl-CoA is used by the enzyme fatty acid synthase (FAS) to create saturated long-chain fatty acids. In NAFLD, the enzyme's hepatic expression and activity are botH extremely high, and its suppression results in lower liver lipid levels and improved insulin sensitivity. Therefore, FAS inhibition reduces hepatic steatosis and de novo lipogenesis [44].
