**3.1 Primary end points**

During the 72 h of treatment, urinary output increased and creatinine improved (**Table 5**). SOFA renal decreased (**Figure 2**). Urinary output increased to 57% and was associated with the increase of P/F ratio and fluid balance (**Tables 5** and **6**).

In **Table 6**, the main hemodynamic changes during the treatment are shown. MAP increased and norepinephrine dosage dropped to low value. This is associated with the changes of SOFA cardio.

SOFA total decreased, too, as a result of this global clinical improvement (**Figure 2**).
