**3.3 Adverse events**

Clotting of the filter (5/20) and minor bleeding (8/20) were the most common events in patients with heparine anticoagulation. Patients with citrate anticoagulation developed acid-base disturbance (metabolic acidosis 7/70, lactic acidosis 5/70), clotting of the filter (10/70), and two episodes of HIT not related completely to the CRRT treatment. In the patients treated without anticoagulation, clotting of the filter was a common event (6/11).
