**3. Results**

From January 2012 to September 2020, 143 patients with sepsis septic shock (Sepsis III definition) and AKI (AKIN classification) required ICU admission to Aurelia Hospital and European Hospital in Rome.

Among these patients, after the revision of the clinical data stored in the clinical informatic platform, 42 patients have been excluded from the study, as they did not fulfill the inclusion criteria (**Figure 1**).

#### **Figure 1.**

*Enrollment of the patients in the study. From 143 patient referred to the two intensive care AURELIA HOSPITAL and EUROPEAN HOSPITAL finally 101 patients were enrolled in the study.*

In total, 101 patients with sepsis/septic shock and AKI (AKIN criteria) received CRRT with oXiris filter and completed the study. In **Tables 3** and **4**, the main basal anthropometric and clinical data are reported. All patients received intensive care treatment in accordance with the Survive Sepsis Campaign Bundle. The initial prescription was continuous venovenous hemodiafiltration (CVVHDF), as reported in **Table 1**. Data on anticoagulation are shown in **Table 2**.

For the 101 patients included in the study, we analyzed the protocol data at basal time (T0) and after 72 h of treatment (T1). All patients included in the study were also stratified on AKIN criteria, and the changes between these groups were also evaluated.
