**3.1 Platelet Adhesion in T1DM**

In T1DM, there is evidence of increased platelets adherence to surfaces such as collagen and fibrinogen [19–21], and this corresponds to elevated plasma vWF Ag and activity [22] and low ADAMTS-13 Ag and activity [23]. These features are related to glycemic control [24] and only if vWF is present and elevated in plasma [25].

However, it is not yet established whether the increased adhesiveness are linked to aggregation and linked to or derived from ensuing endothelial injury.
