**5.5 Inflammation**

Inflammation is common to both T1DM and T2DM. However, in T1DM inflammation is upstream involving cellular interactions that release cytokines and fibrinogen [127]. The cytokines and fibrinogen have been found to influence platelet activation independent of hyperglycemia [123, 128]. Since fibrinogen is an acute phase protein

associated with acute inflammatory conditions, its correlation with platelet functions points to the role of inflammation in the modulation platelet response after stimulation.
