**6.8 Platelet-Neutrophil interaction**

Animal studies have provided evidence for indirect platelet activation in DM that in the presence of hyperglycemia, neutrophils are stimulated to release S-100 calcium-binding proteins A8/A9 that lead to production of TPO from the liver. The released TPO consequently acts on bone marrow megakaryocytes to release reticulocytes [16]. Reticulocytes have high surface expression of GPIIbIIIa, P-selectin, and release cytokines [16]. The expressed P-selectin interacts with SGL-P on neutrophils to release neutrophil extracellular traps (NETs).
