*The Role of Apoptosis in Autoimmune Destruction of Pancreatic b-Cells DOI: http://dx.doi.org/10.5772/intechopen.108290*

Insulin may have a potential positive effect in preventing disease at the preclinical stage, due to its potential immunomodulatory effect and its ability to induce b-cell "rest" [5].

Considering the numerous mechanisms by which apoptosis affects individual stages of the pathogenesis of T1DM, it is advisable to consider possible ways of its modulation in order to influence certain targets of the pathological process for therapeutic purposes.
