**5. Modifiers of platelet function**

Although platelet hyperactivity are vital to the pathophysiology of diabetes mellitus [42, 50–52], there are other factors in systemic circulation that modify disease progression. These factors include hyperglycemia and its control, insulin deficiency and therapy, acute metabolic acidosis, inflammatory markers that precede and coexist during disease states, and body calcium-magnesium fluxes levels.
