*4.1.4 Long-acting insulins*

Insulin glargine (Lantus) and insulin detemir (Levemir) are long-acting insulins. Insulin glargine is slow dissolution at the injection site, resulting in a relatively constant and peakless delivery over 24 hours. it is usually given at bedtime. However, it can be given before any meal, but, whichever time is chosen, it must be given constantly at that time. Insulin determir is absorbed relatively quickly from the subcutaneous tissue and then binds to albumin in the bloodstream, resulting in a lengthy action time of approximately 17 hours. Generally, it is given twice a day. It decreases the chances of nocturnal hypoglycemia (**Table 7**).


*Adapted from Kaufman FR editor: Medical management of type 1 diabetes, ed 6, Alexandria, Va, 2012, American Diabetes Association.*

### **Table 5.**

*Regular insulin.*


*Adapted from Kaufman FR editor: Medical management of type 1 diabetes, ed 6, Alexandria, Va, 2012, American Diabetes Association.*

## **Table 6.** *Intermediate-acting insulin.*


## **Table 7.**

*Long-acting insulin.*


*Adapted from Kaufman FR editor: Medical management of type 1 diabetes, ed 6, Alexandria, Va, 2012, American Diabetes Association.*
