**4. Platelet: inflammation cross talk in T1DM**

There is cross talk between inflammation and platelets in T1DM where leukocytes and platelets activate each other [45] and both leukocytes, especially monocytes, and platelets are hyperactivated [41, 46]. Whereas platelets release cytokines [47], and increased levels of these factors have been found in circulation in individuals with T1DM [40], a cause and effect relationship has been questioned [48]. What is known is that cytokines, especially IL-6 and IL-8, are platelet activators [49], but whether they are the cause of platelet hyperactivity in T1DM remains largely unknown.
