**6. Conclusion and perspectives**

A potentially promising therapeutic option for diabetes (especially T1DM) treatment can be stem cell treatment, as it cures the disease rather than treating or managing them. Major advances in research on the derivation of IPCs from hPSCs have improved our chance of reestablishing glucose-responsive insulin secretion in patients with T1DM. There are many questions and technical hurdles that still need to be solved.

The major problems include the following five aspects:


Despite these obstacles, the application of stem cell-based therapy for T1DM represents the most advanced approach for curing type 1diabetes.
