*5.4.3 Statins*

In patients with hyperlipidemia type II, statins reduced ADP-induced platelet aggregation regardless of the type of drug. However, there was no change with collagen or ristocetin agonist. In addition, the changes were not observed in fibrinogen levels, spontaneous aggregation, and adhesion [125]. The effect of lipid lowering agents in attenuating platelet functions appears to be related to changes in fibrinogen levels [126], suggesting modulation through inflammatory mediators.
