**1. Introduction**

Diabetes mellitus (DM) is a metabolic disorder characterized by high blood glucose levels. There are two major types: type 1DM (T1DM) or insulin-dependent DM (IDDM) due to insulin deficiency or absence; and type 2 DM (T2DM) or non-insulindependent DM (NIDDM) is due to insulin resistance.

Diabetes mellitus and impaired glucose tolerance are associated with cardiovascular risk [1, 2] and thrombosis [3] considered to be platelet in origin [4]. Data on platelet functions have largely been derived from T2DM, since it is the most prevalent. However, T1DM is unique in that platelets are exposed to hyperglycemia in the absence of insulin, while in T2DM they are exposed to both hyperglycemia and hyperinsulinemia. It is increasingly debatable the roles of these factors in alteration of platelet functions in T1DM owing to the acuteness and short duration of exposure. More so, the role of insulin on platelet functions is controversial [5] given the paucity of its receptors [6], and that the platelet glucose transporters are independent of it [6].
