**2.1 Platelet indices**

Platelet indices such as platelet count, mean platelet volume (MPV), platelet distribution width (PDW), and platelet large cell ratio (P-LCR) are elevated in patients with IDM type 1 than non-diabetic controls [7] and are associated with cardiovascular complications [8]. These strongly correlate with duration of blood sugar control as assessed by extent of HbA1c [9] suggesting link with metabolic impairment. Notably, MPV size positively correlated with fasting blood glucose and HbA1C [10]. However, as to whether these changes are due to glucose and attendant osmotic effects or part of disease process remains largely unexplored.
