**5.3 Hypertriglyceridemia/hyperlipidemia**

In T1DM, the frequency of occurrence of hyperlipidemia is variable [95–97], but when it occurs is associated with platelet hyper-activation [46] and aggregation [98]. The link between post-prandial lipids and platelet secretions [99] and aggregations has been known for a long time [100]. The case was made stronger by observations that treatments lowering the plasma lipids led to normalization of platelet aggregation [101] and glycoprotein expression [102]. Hyper lipidemia associated with uncontrolled T1DM thus becomes an added dimension in platelet hyperactivity together with roles of glucose and insulin.
