**6.1 Oxidative stress**

Owing to the absence or deficiency of insulin in T1DM glucose undergoes auto-oxidation with accumulation of reactive oxygen species [129]. The consequence is peroxidation of membrane lipids and proteins [130] promoting platelet aggregation [131].

However, it is still controversial whether oxidative stress is a consequence of metabolic complications in T1DM or the cause of the disease [47].
