*1.3.6 Pathogenesis of type 1 diabetes*

Type 1 diabetes is an insulin-dependent type of diabetes with an onset in childhood extending to early adulthood (≤ 30 years old); however, any age group can be affected.

Its pathogenesis involves three interlinked mechanisms:

Genetic susceptibility, immune system regulation abnormalities, and environmental factors; however, for type 1 b, the pathogenesis is idiopathic. The HLA locus on chromosome P21 contributes about 50% of susceptible genes. The HLA molecules
