**Acknowledgements**

This work was funded in part by PE-0106-2019 from the Consejería de Salud de la Junta de Andalucía, C19047-2018 from Fundación Unicaja and UMA18-FEDERJA-042 from UMA-FEDER & ALIANZA MIXTA ANDALUCÍA-ROCHE. María Isabel Queipo Ortuño is recipient of a "Miguel Servet Type II" program (CPI13/00003) from ISCIII, co-funded by the Fondo Europeo de Desarrollo Regional-FEDER, Madrid, Spain and also belongs to the regional "Nicolas Monardes" research program of the Consejería de Salud (C-0030-2018, Junta de Andalucía, Spain. Alicia González González is recipient of a postdoctoral grant Margarita Salas (RMS-08) from European Union-NextGenerationEU, Spanish Ministry of Universities and Recovery Transformation and Resilience Plan, through a call from University of Cantabria. Aurora Laborda Illanes is recipient of a predoctoral grant, PFIS-ISCIII (FI19-00112), co-funded by the Fondo Social Europeo (FSE). Lidia Sanchez Alcoholado is recipient of a predoctoral grant (PE-0106-2019) from the Consejería de Salud y Familia (co-funded by the

Fondo Europeo de Desarrollo Regional-FEDER, Andalucía, Spain). Daniel Castellano Castillo is recipient of a postdoctoral grant Sara Borrell (CD21/00164) from Instituto de Salud Carlos III.
