**1. Introduction**

Sjögren's syndrome (SS) is a chronic inflammatory disorder characterized by immune-mediated exocrinopathy (inflammation and lymphoplasmacytic infiltration of the lacrimal and salivary glands) with resulting dysfunction. It can occur primarily or in association with a second well-defined rheumatic disease (secondary form). Both ways, they produce inflammation of the exocrine glands with subsequent dry eye and dry mouth [1, 2].

Patients with Sjögren's syndrome (SS) may present with symptoms suggestive of dry eyes. Dry eye typically manifests itself in up to 95% of SS patients; whose complaints are inability to tear, foreign body sensation, conjunctival inflammation, eye fatigue, and decreased visual acuity [3]. Dry eye disease (DED) can be complicated by keratoconjunctivitis sicca, blepharitis, bacterial keratitis, or corneal ulcer [4]. Uveitis, episcleritis, and orbital pseudotumor are systemic manifestations that rarely occur in patients with Sjogren's syndrome [5].
