**2. Metrics/algorithm to computational biology**

## **2.1 Description of metrics/algorithm**

## *2.1.1 Internal distance*

The internal distance *di* in a particular Voronoi cell, is the distance measured from the internal mathematical node (black dot, see **Figure 1**) of the Voronoi polygon to each neighboring point (blue dot, see **Figure 1**) which forms the polygon. This is an Ulam tree modified to measure distances, **Figure 1**.

## *2.1.2 Angular graph*

The numbers *ψ<sup>i</sup>* are the angles between the horizontal line which contains the internal mathematical node and the line which joins each neighboring point to the internal node, it is measured anticlockwise (Ulam tree modified to angles), **Figure 2**.

**Figure 2.** *Angle measurement between nearby points from a horizontal axis.*
