**Abstract**

This chapter described the ability of Zika virus, a hemostat-borne flavivirus, to infect retinal pigment epithelium cells and to generate chronic inflammation capable of generating permanent damage in the host that can progress eventually to the onset of pathology related to retinal degeneration. In addition, given the lack of an effective vaccine against ZIRK, the possibility of using as a therapeutic strategy the reduction of inflammatory processes that are established as a result of viral infection through the use of bioactive phytonutrients was analyzed.

**Keywords:** retinal degeneration, RPE cells, Zika virus, inflammation, phytonutrients
