**3.5 OCTA and DME**

DME is still a problem for a correct interpretation of OCTA images. In fact, cystic macular edema affects the automatic segmentation of the software and affects image quality. This is especially evident in the DCP, because signal intensity is lower [41]. Cysts may compress the vessel wall, lowering the flow. OCTA can consider these areas as avascular [42].

According to Coscas et al., three patterns of DME can be identified by OCTA [43]:

