**4.6 FDA devices of targeted phototherapy**

Excimer laser machines, which are approved by the FDA, have been introduced by companies such as Alcon (Wave Light®, USA) and PhotoMedex. (XTRAC®; USA). The disadvantages of these equipment include their heavy weight, high cost, and difficult maintenance.

The FDA-approved nonlaser-targeted phototherapy includes Excilite® (DEKA, Florence Italy; 304 nm), Pxlite (308 nm), and Exciplex (Excimer Therapies; 308 nm). These machines are less bulky and cheaper and have a comparatively larger treatment surface than that of the excimer laser.

The nonlaser machines are considerably smaller than the laser machines, with fewer maintenance problems, and are cheaper. They have multiple delivery programs and automatic calibration for quick delivery of dosages so that the treatment time is short. Some of these machines have UVA (330–380 nm) and UVB (narrowband; 290–330 nm) spectra [32–34].
