**4. Disease- and treatment-associated bone deterioration**

There are several diseases and treatments that destabilize the bone remodeling process and induce abnormal bone deterioration (**Figure 1**) [30]. Each disease and treatment act differently on hormones, which conducts various bone problems. In this

**Figure 1.** *Illustration of diseases and medical treatments' effect on BMD, bone matrix, and architecture.*

section, we are summarizing the most-known diseases and treatments affecting bone and their effect on BMD.
