**4. Conclusion**

• The results of the FRAX application show consistency with the results of the LRP5rs121908669 genetic diagnosis and the diagnosis based on the opinion of the clinician more than the compatibility of the results of DEXA with the genetic and clinical diagnosis. The World Health Organization has been contacted in this regard. Syrian Tishreen University is the first discoverer of this idea. This also strengthens the link between Tishreen University research and community services. This is a research service on a global and local level. It can be suggested to add the genetic factor especially LRP5rs121908669 to the application of FRAX. Syrian Tishreen University is proposed this idea for the first time in the world to prof. John Kanis.

