*3.2.8 Results of genetic test (LRP5rs121908669, COL1A2rs72658152) and FRAX vs. DEXA results (1: 0) as a case report*

By comparing the genetic results of the two studied SNPs and the results of the application of FRAX and the results of DEXA for two clinical cases, there was agreement between the results of FRAX and the genetic results without their compatibility with the results of DEXA. The first case is 75 years old. Results of DEXA are osteopenia in the femur bone and normal in the lumbar bone. Results of FRAX are major osteoporotic 20, hip fracture 9.7. Therapeutic intervention is decided by the doctor. The genotype of LRP5rs121908669 is GC. There is not COL1A2rs72658152.

The second case is 45 years old. Results of DEXA are osteoporosis in the femur and lumbar bones. Results of FRAX are major osteoporotic 0.4, hip fracture 0. Therapeutic intervention is not needed as the doctor's opinion. The genotype of LRP5rs121908669 is GG. There is not COL1A2rs72658152.

The results of DEXA conflict with the opinion of the specialist, while the results of FRAX agree with the opinion of the specialist. Genotypes of LRP5rs121908669 agree with the FRAX results, but vary with DEXA radiographic findings. FRAX is not a diagnosis tool. FRAX is for predicting fractures. But logically, it can be used in the validity of the current diagnosis, especially with the existence of the problem of the approved criteria (DEXA).

When a case is diagnosed as osteoporosis and requires therapeutic intervention according to the approved criteria, then FRAX is applied and the results are not predictive of fractures. Illogical something has been facing (case2). Or, when the case is not diagnosed as osteoporosis FRAX is applied and the results are predictive of fractures. In fact, this case requires therapeutic intervention, although it does not conform to the standards of the World Health Organization (case1). This requires more studies for comparing the results of FRAX with the results of DEXA on a larger scale of samples. This comparison is the first of its kind in the world.
