**8. Treatment**

There is no specific medical treatment for LS. It must be kept in mind that preadipocytes remain present at lipoatrophic lesions and new adipocytes make recovery always possible [56]. Most cases regress with time in variable periods, ranging from weeks to months, (sometimes spontaneously [30]) or even years. Some authors reported regression lapses between 9 months to 4 years [17], while others described 93% of clinical regression after 6 months (complete 62% and partial 32%) [87]; in other reports of 30 cases, 75% showed a favorable evolution after 3 months, with total regression of lesions in 43.4%, partial in 30.4%, and without changes in 26.2% [88]. If a predisponent factor is detected and avoided, impairment will be faster [12, 13, 15, 16, 26]. In a series of seven cases, the time taken for lesion improvement varied between 2 weeks and 4 months after stopping leaning against the desks or after smooth barriers were fitted along the edges of the tables [48]. However, lesions may also disappear without following any specific indication [30], or without being discovered the origin of the mechanical trauma [17]. Spontaneous remissions have been observed in 24 workers after holidays away from their workplace [63], or after stopping working due to pregnancy leave, absence from work for long periods, or on retirement [50].

## **8.1 Preventive measures and corrective actions**

Preventive measures and corrective actions [7, 51, 57, 65, 66, 87, 89] are crucial for the treatment of this condition, and can be divided into distinct areas:
