**5.5 UBAC2 and LACC1**

Ubiquitin-associated domain containing 2 (UBAC2) encodes an ubiquitinationrelated structural domain that is implicated in ubiquitination and proteasomal degradation. The association of the UBAC2 gene polymorphisms (rs9513584, rs9517723, rs7999348) with BD were found in multiple cohorts found including Turkish, Chinese Han, Italian, and Japanese populations [125–128]. The LACC1 (Laccase domain-containing 1), also known as multicopper oxidoreductases, encodes an oxidoreductase that promotes fatty-acid oxidation. It known functions in activation of inflammasome, bactericidal activity of macrophages, and production of mitochondrial and NADPH-oxidase-dependent reactive oxygen species. SNP rs9316059 of the LACC1 was associated with BD in all the populations tested including Chinese Han, Turkish, Iranian and Japanese [91, 129].
