**4.2 FCRL3**

The Fc receptor-like (FCRL) family is a recently recognized potential immunoregulatory cell surface molecule. FCRL3 is predominantly expressed in germinal centers of lymphoid organs and has been linked to B cell maturation [76]. FCRL3 may be involved in the mechanisms regulating Treg dysfunction, which may in turn contribute to the loss of self-tolerance and development of autoimmunity [77]. The -110 G allele and CGCG haplotype of FCRL3 were found to be associated with BD, while the ATCG haplotype was found to be protective for BD in a Chinese population [78]. In a study with Iranian BD patients, there was a significant difference demonstrated between groups at position -169 (rs7528684) of FCRL3 gene [79].
