**5.7 ROCK1 and ROCK2**

The Rho-kinase (ROCK) family members, consisting of ROCK1 and ROCK2, play significant roles in the actin cytoskeleton organization and regulate a wide range of fundamental cellular functions, such as adhesion, migration, motility, cell proliferation, apoptosis, and multiple inflammatory responses [135, 136]. Oguz et al. showed the SNPs rs73963110, rs112130712, rs111874856, rs112108028 might increase the susceptibility to Behçet's disease, but they failed for the other SNPs such as rs35996865, rs111312709 and rs2271255 [137]. In addition, the ROCK2 gene rs35768389 (Asp601Val) polymorphism was showed to be associated with BD and the C allele was significantly higher in BD patients compared to controls [138].

## **5.8 VDR gene**

The proven role of vitamin D in innate and adaptive immune responses has led to an increase in studies on the relationship between vitamin D and autoinflammatory diseases. The VDR gene encodes the VDR protein, a member of the nuclear receptor

*Genetics of Behçet's Disease DOI: http://dx.doi.org/10.5772/intechopen.101342*

superfamily, that is essential for the biological functions of vitamin D [139, 140]. Karray et al. found that the VDR gene (rs1544410 and rs2228570) polymorphism were associated with BD in Tunisian patients [141]. In a study with a Turkish cohort, the VDR gene rs1544410 A allele and rs2228570 C allele were reported to be a risk factor for BD susceptibility [142]. In a meta-analysis, the role of the four common VDR polymorphisms has been investigated and it was suggested that rs731236 polymorphism might be a risk factor for BD [143].
