**5. Histopathological features**

The intraoral ulcers are nonspecific, and are similar to recurrent aphthous ulcers according to Lehner. Endothelial proliferation has been observed in the lesions of Behçet's disease but not in the recurrent aphthous ulcer [1, 22, 23].

Perivascular infiltrate of mononuclear cells; mast cell infiltrate and neutrophilic vasculitis may be found. Papulopustular lesions with spongiosis, basal keratinocyte vacuolization, intraepidermal pustules and suppurative folliculitis are seen [1, 22, 23].

Vasculitis also appears to be an essential lesion in Behçet's disease, thrombi in vessel lumens, perivascular inflammatory infiltrate are also observed [1, 22, 23].

#### **6. Management**

Type of management depends on the organ affected and its severity. Therapeutic options according to the disease type, severity, age, and sex of each patient must be categorized. Investigations are mainly nonspecific indices of inflammation that include leukocytosis, elevated ESR and CRP [24–26].

The severity of the syndrome usually abates with time. Ocular, vascular, and neurologic disease, require more aggressive treatment. Corticosteroids, colchicine, azathioprine, cyclosporine, thalidomide, cyclophosphamide, Interferon-α and tumor necrosis factor-α inhibitors can be prescribed [24–26].

Apart from patients with central nervous system- Behçet's disease and major vessel disease, the life expectancy is normal. The only other serious complication is blindness [24–26].

## **7. Conclusion**

Although the exact cause of Behçet's disease is unknown, genes, environmental triggers, and an abnormal immune response may be possible causes. In severe cases, there's a risk of serious and potentially life-threatening manifestations, such as blindness and strokes.

Majority of the people exhibit episodes where their symptoms are severe (flareups or relapses), followed by periods where the symptoms disappear (remission). Therefore, the importance of close scrutiny for lesions in Behçet's disease cannot be overstated.
