**3.2 Modulate the immunosuppressive tumor microenvironment (TME)**

ICT have showed great potential in increasing survival rate in various cancers. However, the low response rate of patients to ICT, which is related to immunosuppressive tumor microenvironments, remains a challenge to be addressed. Several studies have aimed to target and reverse the immunosuppressive TME, so as to increase the therapeutic effects and decrease side effects of ICT (**Figure 3**) [29].
