**3.4 The signal's "scale of preference"**

In a bid to approve the genuineness of a sign, it was essential to take note of the effect of the unfavorable occasion on general wellbeing, as prior expressed. It is important to speedily distinguish the signs with significant general well-being effects or that might influence the advantage risk balance of the clinical items in the treated patients. To organize the size of inclination, the strength and consistency of proof ought to be thought of.

## *3.4.1 Methods of getting the scale of preference*

