**1. Introduction**

Pharmacodynamics (PD) elucidates the relationship of drug's concentration with the body (target), the way it affects and the impact it creates. It can be an ultimate characteristic feature to determine the effects exhibited by the concentration of the drug so as to assure its efficacy and safety. This feature in turn helps to avoid the adverse and toxic reactions caused by the drug that is administered to the body. PD forms a part of pharmacology that deals with the concepts of drug's interaction with any one of the four primary groups of target proteins, namely, ion channels, enzymes, membrane carriers, and receptors, and concentration of drug with respect to time, and the effect caused by the dosage of the drug. Since, the concentration of drug is significantly related to the drug's effect, there are some parameters to confine its efficiency and some advanced computer-based techniques to highlight the concerns in this regard. These kinds of techniques enable PD to unlock the problems occurring while designing a novel drug which could be rectified by the development of precision making medicines through digital therapeutics/treatment. This in-turn paves way for PD to place its remarkable contribution in the phase of personalized medicine design based on the individual's requirement.

This chapter mainly focuses on the advanced technologies in today's trend in order to exemplify the crucial part of drug's PD characteristics in drug discovery process in consideration to human health and also, some of the basic concepts need to be taken into mind, like its importance in drug discovery process and the technologies which escalate the identification of PD of a drug are discussed in brief.
