**Acknowledgements**

The authors would like to thank the members in National Postdoctoral Research Station of Gansu Provincial Hospital, Hefei Institute of Physical Science, Chinese Academy of Sciences, and Institute of Health-Biotech, Health-Biotech (Tianjin) Stem Cell Research Institute Co., Ltd. for their technical support. We also thank the staff in Beijing Yunwei Biotechnology Development Co., LTD for their language editing service. This study was supported by grants from the project Youth Fund funded by Shandong Provincial Natural Science Foundation (ZR2020QC097), the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (2019PT320005), Science and technology projects of Guizhou Province (QKH-J-ZK [2021]-107), the project Youth Fund funded by Jiangxi Provincial Natural Science Foundation (S2021QNJJL0277), Jiangxi Provincial Key New Product Incubation Program from Technical Innovation Guidance Program of Shangrao city (2020G002, 2020 K003), Natural Science Foundation of Tianjin (19JCQNJC12500), Jiangxi Provincial Novel Research and Development Institutions of Shangrao City (2020AB002, 2021F013).
