We are IntechOpen, the world's leading publisher of Open Access books Built by scientists, for scientists

6,400+

Open access books available

173,000+

International authors and editors

190M+ Downloads

156 Countries delivered to Our authors are among the

Top 1% most cited scientists

Contributors from top 500 universities

Selection of our books indexed in the Book Citation Index in Web of Science™ Core Collection (BKCI)

### Interested in publishing with us? Contact book.department@intechopen.com

Numbers displayed above are based on latest data collected. For more information visit www.intechopen.com

## IntechOpen Book Series Biochemistry

Volume 43

### Aims and Scope of the Series

Biochemistry, the study of chemical transformations occurring within living organisms, impacts all of the life sciences, from molecular crystallography and genetics, to ecology, medicine and population biology. Biochemistry studies macromolecules - proteins, nucleic acids, carbohydrates and lipids –their building blocks, structures, functions and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins and hormones, which play roles in the life process. Biochemical experimentation, besides coopting the methods of classical chemistry, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the 'big data' omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying and examining individual components of a biological system; in exemplary words of Efraim Racker, (1913 –1991) "Don't waste clean thinking on dirty enzymes." Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe fully a particular biological system. The 'big data' metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the proteins comprising e.g., serum; metagenomics can identify all the genes in a complex environment e.g., the bovine rumen.

This Biochemistry Series will address both the current research on biomolecules, and the emerging trends with great promise.

## Meet the Series Editor

Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg's research is focused

on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.

## Meet the Volume Editors

Suna Sabuncuoğlu, professor in the Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Hacettepe University, Turkey, graduated from the same institution, completing a Ph.D. in pharmaceutical toxicology. As a Ph.D. student, she worked at the International Agency for Research on Cancer, Molecular Carcinogenesis Laboratory. She also held a postdoctoral position at the Department of Chemotherapy and Virology, Rega Institute, The

Catholic University of Leuven, Belgium. Suna Sabuncuoğlu became a lecturer in 2013 and an associate professor in 2014. She has served on many different boards, commissions and centers within and outside the university. Since 2018, she has held the title of European Registered Toxicologist (ERT).

Ahmet Yalcinkaya, MD, Ph.D., graduated from medical school in 2013 and worked as an ER physician for nearly two years. He began his Ph.D. in the Medical Biochemistry Department of Hacettepe University Faculty of Medicine and defended his thesis in 2020. During his Ph.D., he received a grant for cancer and immunology research at the Medical University of South Carolina, USA, and worked at the Hollings Cancer Center, Department of Biochemis-

try and Molecular Biology from 2019 to 2020. His current postdoctoral research at the Department of Medical Biochemistry and Microbiology, Uppsala University, Sweden, explores the antibody-mediated origins of immune and infectious diseases.

### Contents


