**3. Diagnosis**

The Mayo Clinic diagnostic criteria for stress cardiomyopathy must include all four of the following for diagnosis:


#### *Takotsubo Cardiomyopathy DOI: http://dx.doi.org/10.5772/intechopen.113269*

Presentation often mimics acute coronary syndrome (ACS): chest pain, ST elevations on electrocardiography, and elevated cardiac biomarkers. Diagnostic coronary angiography is typically performed revealing normal or nonobstructive coronary artery disease in the vast majority of patients. It is estimated that approximately 2% of all patients undergoing emergent coronary angiography for presumed ACS have TTS [3]. Though ACS and TTS may share similar features, theorized pathogenesis, management, and prognosis of TTS is unique.
