**7. Conclusion**

This review overlays the aspects of gene mutations relevant to mitochondrial energetics, cardiomyocyte function, and LV myocardial noncompaction. Understanding the rudimentary causes of LVNC imparts helpful information in the prognostic evaluation and early diagnosis of LV noncompaction. Further examination of mitochondrial involvement in cardiac noncompaction leading to heart failure would facilitate advances in the therapeutic treatment of this disease process.
