**6. Outcomes**

Historically, Takotsubo syndrome was often thought to portend a more benign course with favorable outcomes compared to ACS. More recent, larger-scale analyses are revealing that up to 50% of patients suffer from acute complications and acute mortality rates similar to ACS. In most patients, recovery of LV function can be seen within 1–6 months. The risk factors that influence rate of LV recovery process are unknown. Concerningly, factors that lead to delayed resolution of wall motion abnormalities also remain unknown. The nebulous nature of this disease course has significant clinical implications. Patients without early LV recovery have higher prevalence of in-hospital complications and higher mortality and should be monitored closely. Patients with persistent wall motion abnormalities also require close monitoring with repeat cardiac imaging. Recurrence rates of TTS average between 2 and 10% [12]. A variable TTS pattern at recurrence is common in up to 20% of recurrence cases (see **Figure 3** for variant patterns of TTS). Despite these findings, few data exist regarding treatment, long-term prognosis, and risk stratification.

**Figure 3.** *Variants of Takotsubo cardiomyopathy.*
